AIMC Topic: Oxidopamine

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Assessing changes in whole-brain structural connectivity in the unilateral 6-hydroxydopamine rat model of Parkinson's disease using diffusion imaging and tractography.

Journal of neural engineering Jul 7, 2025
Parkinson's disease (PD) is a multifactorial, progressive neurodegenerative disease that has a profound impact on those it afflicts. Its hallmark pathophysiology is characterized by degeneration of dopaminergic (DA) neurons in the midbrain which trig...
Brain Animals Male Rats Rats, Sprague-Dawley Disease Models, Animal Parkinson Disease Neural Pathways Nerve Net Diffusion Tensor Imaging Diffusion Magnetic Resonance Imaging Oxidopamine
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Machine learning-assisted neurotoxicity prediction in human midbrain organoids.

Parkinsonism & related disorders May 8, 2020
INTRODUCTION: Brain organoids are highly complex multi-cellular tissue proxies, which have recently risen as novel tools to study neurodegenerative diseases such as Parkinson's disease (PD). However, with increasing complexity of the system, usage of...
Humans Machine Learning Microscopy, Confocal Flow Cytometry Proof of Concept Study Dopaminergic Neurons Neurotoxicity Syndromes Induced Pluripotent Stem Cells Oxidopamine Organoids Mesencephalon
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A Machine Learning Approach to Automated Gait Analysis for the Noldus Catwalk System.

IEEE transactions on bio-medical engineering Aug 24, 2017
OBJECTIVE: Gait analysis of animal disease models can provide valuable insights into in vivo compound effects and thus help in preclinical drug development. The purpose of this paper is to establish a computational gait analysis approach for the Nold...
Machine Learning Female Animals Male Mice Disease Models, Animal Mice, Inbred C57BL Signal Processing, Computer-Assisted Walking Gait Parkinsonian Disorders Pattern Recognition, Automated Gait Analysis Foot Oxidopamine
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