Integrating machine learning (ML) into nanotechnology represents a promising strategy for rational design and accelerated development of drug delivery systems. However, studies in this field are scarce and face methodological and interpretative probl...
Oral administration is an ideal method for drug delivery, but achieving targeted drug delivery to the colon remains a challenge. In this study, a magnetic microrobot incorporating a colon-specific method was developed, featuring both time-dependent a...
Achieving high resolution while minimizing contrast agent dosage remains a key goal, yet a major challenge in contrast-enhanced computed tomography (CT) imaging. Herein, we propose an artificial intelligence-assisted low-dose high atomic number contr...
OBJECTIVE: This review synthesizes atmospheric chemistry, toxicology, and environmental justice to assess public health risks from ultrafine particles (UFPs, <100 nm) in Wildland-Urban Interface (WUI) fire smoke. It explores UFP emission sources, tra...
International journal of pharmaceutics
Oct 4, 2025
The transition from traditional batch to continuous pharmaceutical manufacturing puts additional demands on the efficient process development and operation. The comprehensive understanding of complex interdependencies between critical process paramet...
A comprehensive understanding of protein corona (PC) composition is critical for engineering nanoparticles (NPs) with optimal safety and therapeutic performance, because the PC governs NP pharmacokinetics, biodistribution, and cellular interactions. ...
International journal of pharmaceutics
Sep 28, 2025
Dry powder inhalers (DPIs) are widely used for pulmonary drug delivery, and their aerodynamic performance is highly dependent on particle surface morphology. This paper presents a machine learning-based framework to quantitatively predict DPI aerodyn...
In early cancer diagnosis, extracellular vesicles (EVs) are more advantageous than circulating tumor cells due to their smaller size, greater stability, and enhanced tissue penetration. These qualities lead to higher EV concentrations in body fluids,...
The development of dry powder inhalers (DPIs) for pulmonary drug delivery is complex, requiring optimization of variable factors to ensure effective lung deposition. This study investigates the factors influencing the dispersibility of glycopyrronium...
Ultrafine particles (UFP, < 100 nm) are abundantly emitted by aircraft, but quantifying their contributions to ambient particle number concentrations (PNC) is challenging due to confounding from local traffic and complex interactions between aircraf...
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