Physical stability of an active pharmaceutical ingredient (API) is a key consideration in the development of a pharmaceutical drug. Solution conditions such as pH, excipient concentrations, and storage temperatures can impact the physical stability o...
The health risks associated with excessive sodium intake have prompted an exploration of natural salt substitutes. This study was oriented to explore the salty peptides from enzymatic and fermented products of wheat gluten (WG) with different degrees...
Metaproteomics offers a powerful window into the active functions of microbial communities, but accurately identifying peptides remains challenging due to the size and incompleteness of protein databases derived from metagenomes. These databases ofte...
Tyrosinase plays a central role in melanin biosynthesis, and its dysregulation has been implicated in the pathogenesis of various pigmentation disorders. The precise identification of tyrosinase inhibitory peptides (TIPs) is critical, as these bioact...
Forensic body fluid identification is crucial for reconstructing crime scene events. While DNA analysis provides individualization, it lacks information about the fluid's origin. We developed and evaluated three complementary proteomic approaches usi...
This research employed integrated machine learning and bioinformatics approaches to identify umami-enhancing peptides from Flammulina filiformis, elucidate their mechanisms of umami augmentation, and validate their efficacy through sensory evaluation...
Journal of chemical information and modeling
Sep 26, 2025
Signal peptides and transit peptides are essential for directing mature proteins to their proper cellular locations, particularly through cleavage following transport. Although various prediction tools achieve strong performance in identifying and cl...
The identification of bitter peptides is crucial in various domains, including food science, drug discovery, and biochemical research. These peptides not only contribute to the undesirable taste of hydrolyzed proteins but also play key roles in physi...
Journal of chemical information and modeling
Sep 18, 2025
With the increasing discovery of peptide sequences and the growing demand for peptide-targeted drugs, traditional wet-lab experiment methods have become inadequate for peptide function prediction due to their high cost and that they are time consumin...
Marine bioactive peptides (MBPs) are short-chain amino acid polymers derived from marine sources that possess specific physiological activities. Owing to their unique origins and structural diversity, MBPs have attracted considerable research interes...
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