Anticancer peptides (ACPs) are acknowledged for their potential in cancer therapy, attributed to their safety, low side effects, and high target specificity. However, the discovery of ACPs is slowed by the high cost and labor-intensive nature of expe...
Interleukin-6 (IL-6) is a cytokine with diverse biological activities that contribute to a variety of physiologic and immune responses. IL-6-inducing peptides are the short protein fragments that are critical for playing a contributing role in biolog...
Class Ι major histocompatibility complexes (MHC-Ι), encoded by the highly polymorphic HLA-A, HLA-B, and HLA-C genes in humans, are expressed on all nucleated cells. Both self and foreign proteins are processed to peptides of 8-10 amino acids, loaded ...
Peptides, derived primarily from natural bioactive sources, play essential roles in human physiological processes such as hormone regulation and nerve signal transmission. Recent advances in phage display technology have revolutionized peptide screen...
Chemical communications (Cambridge, England)
Jun 24, 2025
Recurrent neural networks underwent reinforcement procedures for generation of peptide binders with desired properties. Docking and scoring of peptides from these models allowed enrichment of focused sets with validated sequences for iterative fine-...
Environmental pollution by miniaturized plastics such as micro- and nanoplastics continues to escalate, posing serious risks to ecosystems and human health. Therefore, there is an urgent need to detect or identify the plastics. Although the technique...
Self-assembled peptide hydrogels have emerged as a research frontier in biomedical engineering due to their exceptional water-retention capacity and spatiotemporal drug release kinetics. Researchers can fabricate biomaterials with customizable struct...
OBJECTIVE: Alzheimer's disease poses a significant threat to human health. Currenttherapeutic medicines, while alleviate symptoms, fail to reverse the disease progression or reduce its harmful effects, and exhibit toxicity and side effects such as ga...
Journal of chemical information and modeling
Jun 6, 2025
Viral infections have long been a core focus in the field of public health. Antiviral peptides (AVPs), due to their unique mechanisms of action and significant inhibitory effects against a wide range of viruses, exhibit tremendous potential in protec...
In this study, we identified and screened nine novel umami peptides derived from yellowfin tuna (Thunnus albacares) utilizing peptidomics combined with various machine learning based umami screening methodologies, including UMPred-FRL, TPDM, Umami-MR...
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