AIMC Topic: Peristalsis

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Mechanics of small intestine motility for oral macromolecular delivery: modelling segmentation versus peristalsis.

Drug delivery
Intestinal motility, including peristalsis and segmentation, drives complex fluid movements critical for the oral delivery of biologics and other macromolecules. Despite advances, oral delivery remains commercially limited by low bioavailability, oft...

A 3D model predicts behavior of a soft bodied worm robot performing peristaltic locomotion.

Bioinspiration & biomimetics
The passive compliance of a soft worm-like body can be a key advantage for traversal of complex confined spaces, but in practice, the body's stiffness and contact friction often require experimental adjustments. Here, for the first time, we develop a...

Toward automatic and reliable evaluation of human gastric motility using magnetically controlled capsule endoscope and deep learning.

Scientific reports
In this paper, we develop a combination of algorithms, including camera motion detector (CMD), deep learning models, class activation mapping (CAM), and periodical feature detector for the purpose of evaluating human gastric motility by detecting the...

CPG-based neural control of peristaltic planar locomotion in an earthworm-like robot: evaluation of nonlinear oscillators.

Bioinspiration & biomimetics
Earthworm-like robots have excellent locomotion capability in confined environments. Central pattern generator (CPG) based controllers utilize the dynamics of coupled nonlinear oscillators to spontaneously generate actuation signals for all segments,...

Pain-free oral delivery of biologic drugs using intestinal peristalsis-actuated microneedle robots.

Science advances
Biologic drugs hold immense promise for medical treatments, but their oral delivery remains a daunting challenge due to the harsh digestive environment and restricted gastrointestinal absorption. Here, inspired by the porcupinefish's ability to infla...

An earthworm-like modular soft robot for locomotion in multi-terrain environments.

Scientific reports
Robotic locomotion in subterranean environments is still unsolved, and it requires innovative designs and strategies to overcome the challenges of burrowing and moving in unstructured conditions with high pressure and friction at depths of a few cent...

A pipeline inspection robot for navigating tubular environments in the sub-centimeter scale.

Science robotics
In complex systems like aircraft engines and oil refinery machines, pipeline inspection is an essential task for ensuring safety. Here, we proposed a type of smart material-driven pipeline inspection robot (weight, 2.2 grams; length, 47 millimeters; ...

Deep learning-based artificial intelligence model for identifying swallow types in esophageal high-resolution manometry.

Neurogastroenterology and motility
BACKGROUND: This study aimed to build and evaluate a deep learning, artificial intelligence (AI) model to automatically classify swallow types based on raw data from esophageal high-resolution manometry (HRM).

An Analysis of Peristaltic Locomotion for Maximizing Velocity or Minimizing Cost of Transport of Earthworm-Like Robots.

Soft robotics
Earthworm-like peristaltic locomotion has been implemented in >50 robots, with many potential applications in otherwise inaccessible terrain. Design guidelines for peristaltic locomotion have come from observations of biology, but robots have empiric...

In-plane gait planning for earthworm-like metameric robots using genetic algorithm.

Bioinspiration & biomimetics
Locomotion of earthworm-like metameric robots results from shape changes of deformable segments. Morphologically, the segments could stretch, contract or bend by changing their states. Periodic shape changes are recognized as gaits of the robots. Rob...