AIMC Topic: Pharmacogenetics
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Experimental AI chatbot tackles pharmacogenomics questions.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
Sep 23, 2024
Building Nursing Knowledge to Meet the Needs of Disruptive Technology Healthcare Re-Design.
Studies in health technology and informatics
Dec 15, 2021
This paper provides a discourse based upon the key development of nursing in response to the emerging 4Ds of health technology re-design. Building informatics capability among health professionals is a workforce issue necessitated through the increas...
Drug sensitivity prediction from cell line-based pharmacogenomics data: guidelines for developing machine learning models.
Briefings in bioinformatics
Nov 5, 2021
The goal of precision oncology is to tailor treatment for patients individually using the genomic profile of their tumors. Pharmacogenomics datasets such as cancer cell lines are among the most valuable resources for drug sensitivity prediction, a cr...
DeepDRK: a deep learning framework for drug repurposing through kernel-based multi-omics integration.
Briefings in bioinformatics
Sep 2, 2021
Recent pharmacogenomic studies that generate sequencing data coupled with pharmacological characteristics for patient-derived cancer cell lines led to large amounts of multi-omics data for precision cancer medicine. Among various obstacles hindering ...
PharmGKB, an Integrated Resource of Pharmacogenomic Knowledge.
Current protocols
Aug 1, 2021
The Pharmacogenomics Knowledgebase (PharmGKB) is an integrated online knowledge resource for the understanding of how genetic variation contributes to variation in drug response. Our focus includes not only pharmacogenomic information useful for clin...
Opportunities and challenges for the computational interpretation of rare variation in clinically important genes.
American journal of human genetics
Apr 1, 2021
Genome sequencing is enabling precision medicine-tailoring treatment to the unique constellation of variants in an individual's genome. The impact of recurrent pathogenic variants is often understood, however there is a long tail of rare genetic vari...
The Human Phenotype Ontology in 2021.
Nucleic acids research
Jan 8, 2021
The Human Phenotype Ontology (HPO, https://hpo.jax.org) was launched in 2008 to provide a comprehensive logical standard to describe and computationally analyze phenotypic abnormalities found in human disease. The HPO is now a worldwide standard for ...
Deep learning of pharmacogenomics resources: moving towards precision oncology.
Briefings in bioinformatics
Dec 1, 2020
The recent accumulation of cancer genomic data provides an opportunity to understand how a tumor's genomic characteristics can affect its responses to drugs. This field, called pharmacogenomics, is a key area in the development of precision oncology....
Antidepressant pathways of the Chinese herb through genetic ontology analysis.
Journal of integrative neuroscience
Jun 30, 2020
Active compounds and corresponding targets of the traditional Chinese herb, were obtained from systems pharmacological database and placed into ClueGO for gene ontology analysis. The targets of depression were obtained from the Online Mendelian Inhe...
Evaluation of clinical impact of pharmacogenomics knowledge involved in CPIC guidelines on Chinese pediatric patients.
Pharmacogenomics
Feb 1, 2020
To evaluate the clinical benefits of implementing pharmacogenomics testing for Chinese pediatric patients. Based on the drug-gene interactions involved in the Clinical Pharmacogenetics Implementation Consortium guidelines, whole-genome sequencing ...
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