Circulation. Cardiovascular quality and outcomes
28263937
BACKGROUND: Knowledge about drug-drug interactions commonly arises from preclinical trials, from adverse drug reports, or based on knowledge of mechanisms of action. Our aim was to investigate whether drug-drug interactions were discoverable without ...
Networks are well suited to display and analyze complex systems that consist of numerous and interlinked elements. This study aimed at: (1) generating a series of drug prescription networks (DPNs) displaying co-prescription in community-dwelling elde...
MOTIVATION: The use of drug combinations, termed polypharmacy, is common to treat patients with complex diseases or co-existing conditions. However, a major consequence of polypharmacy is a much higher risk of adverse side effects for the patient. Po...
The simultaneous administration of multiple drugs increases the probability of interaction among them, as one drug may affect the activities of others. This interaction among drugs may have a positive or negative impact on the therapeutic outcomes. T...