AIMC Topic: Polypharmacy

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Network-Based Assessment of Adverse Drug Reaction Risk in Polypharmacy Using High-Throughput Screening Data.

International journal of molecular sciences Jan 17, 2019
The risk of adverse drug reactions increases in a polypharmacology setting. High-throughput drug screening with transcriptomics applied to human cells has shown that drugs have effects on several molecular pathways, and these affected pathways may be...
Humans Neural Networks, Computer Algorithms Drug-Related Side Effects and Adverse Reactions High-Throughput Screening Assays Polypharmacy Risk Assessment Drug Design Data Interpretation, Statistical
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Drug-drug interaction extraction from biomedical texts using long short-term memory network.

Journal of biomedical informatics Aug 21, 2018
The simultaneous administration of multiple drugs increases the probability of interaction among them, as one drug may affect the activities of others. This interaction among drugs may have a positive or negative impact on the therapeutic outcomes. T...
Knowledge Bases Medical Informatics Semantics Reproducibility of Results Support Vector Machine Drug Interactions Linear Models Polypharmacy Linguistics Neural Networks, Computer Software Algorithms Language
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Identifying Drug-Drug Interactions by Data Mining: A Pilot Study of Warfarin-Associated Drug Interactions.

Circulation. Cardiovascular quality and outcomes Nov 8, 2016
BACKGROUND: Knowledge about drug-drug interactions commonly arises from preclinical trials, from adverse drug reports, or based on knowledge of mechanisms of action. Our aim was to investigate whether drug-drug interactions were discoverable without ...
International Normalized Ratio Aged Administrative Claims, Healthcare Anticoagulants Registries Aged, 80 and over Polypharmacy Male Data Mining Blood Coagulation Drug Interactions Retrospective Studies Warfarin Pilot Projects Humans Female Atrial Fibrillation Logistic Models Machine Learning Drug Prescriptions Risk Factors Predictive Value of Tests
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Potentially inappropriate polypharmacy is an important predictor of 30-day emergency hospitalisation in older adults: a machine learning feature validation study.

Age and ageing May 31, 2025
BACKGROUND: Machine learning (ML) models in healthcare are crucial for predicting clinical outcomes, and their effectiveness can be significantly enhanced through improvements in accuracy, generalisability, and interpretability. To achieve widespread...
Risk Assessment Time Factors Age Factors Aged Humans Aged, 80 and over Polypharmacy Machine Learning Male Inappropriate Prescribing Female Potentially Inappropriate Medication List Emergency Service, Hospital Reproducibility of Results Geriatric Assessment Risk Factors United Kingdom Hospitalization
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Modeling polypharmacy side effects with graph convolutional networks.

Bioinformatics (Oxford, England) Jul 1, 2018
MOTIVATION: The use of drug combinations, termed polypharmacy, is common to treat patients with complex diseases or co-existing conditions. However, a major consequence of polypharmacy is a much higher risk of adverse side effects for the patient. Po...
Polypharmacy Data Visualization Models, Biological Drug Interactions Drug-Related Side Effects and Adverse Reactions Protein Interaction Maps Humans Computational Biology Neural Networks, Computer Software Female
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The drug prescription network: a system-level view of drug co-prescription in community-dwelling elderly people.

Rejuvenation research Apr 1, 2015
Networks are well suited to display and analyze complex systems that consist of numerous and interlinked elements. This study aimed at: (1) generating a series of drug prescription networks (DPNs) displaying co-prescription in community-dwelling elde...
Age Factors Cluster Analysis Italy Data Mining Pattern Recognition, Automated Practice Patterns, Physicians' Humans Community Pharmacy Services Aged, 80 and over Male Pharmacoepidemiology Time Factors National Health Programs Neural Networks, Computer Databases, Pharmaceutical Female Drug Prescriptions Drug Information Services Aged Independent Living Polypharmacy
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