AIMC Topic: Pre-Eclampsia

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Prediction of obstetrical and fetal complications using automated electronic health record data.

American journal of obstetrics and gynecology
An increasing number of delivering women experience major morbidity and mortality. Limited work has been done on automated predictive models that could be used for prevention. Using only routinely collected obstetrical data, this study aimed to devel...

Prediction model development of late-onset preeclampsia using machine learning-based methods.

PloS one
Preeclampsia is one of the leading causes of maternal and fetal morbidity and mortality. Due to the lack of effective preventive measures, its prediction is essential to its prompt management. This study aimed to develop models using machine learning...

Placental CD4 T cells isolated from preeclamptic women cause preeclampsia-like symptoms in pregnant nude-athymic rats.

Pregnancy hypertension
Preeclampsia (PE), new onset hypertension during pregnancy, is associated with a proinflammatory profile compared to normal pregnancy (NP). We hypothesize that CD4 T cells from PE patient placentas cause PE symptoms during pregnancy compared to those...

Statistical and artificial neural network-based analysis to understand complexity and heterogeneity in preeclampsia.

Computational biology and chemistry
Preeclampsia is a pregnancy associated disease. It is characterized by high blood pressure and symptoms that are indicative of damage to other organ systems, most often involving the liver and kidneys. If left untreated, the condition could be fatal ...

The Pre-Eclampsia Ontology: A Disease Ontology Representing the Domain Knowledge Specific to Pre-Eclampsia.

PloS one
Pre-eclampsia (PE) is a clinical syndrome characterized by new-onset hypertension and proteinuria at ≥20 weeks of gestation, and is a leading cause of maternal and perinatal morbidity and mortality. Previous studies have gathered abundant data about ...

Temporal validation of machine learning models for pre-eclampsia prediction using routinely collected maternal characteristics: A validation study.

Computers in biology and medicine
BACKGROUND: Pre-eclampsia (PE) contributes to more than one-fourth of all maternal deaths and half a million newborn deaths worldwide every year. Early screening and interventions can reduce PE incidence and related complications. We aim to 1) tempor...

Predictive Models Using Machine Learning to Identify Fetal Growth Restriction in Patients With Preeclampsia: Development and Evaluation Study.

Journal of medical Internet research
BACKGROUND: Fetal growth restriction (FGR) is a common complication of preeclampsia. FGR in patients with preeclampsia increases the risk of neonatal-perinatal mortality and morbidity. However, previous prediction methods for FGR are class-biased or ...

Text phrase-mining in identifying and classifying maternal proteins and genes across preeclampsia and similar pathologies.

Physiological reports
This study aims to demonstrate that text phrase-mining and natural language processing (NLP) can annotate huge quantities of obstetrics textual data for the discovery and evaluation of maternal protein/gene (MPG)-disease interactions involved in the ...