Neural computation
Feb 17, 2022
Animals make efficient probabilistic inferences based on uncertain and noisy information from the outside environment. It is known that probabilistic population codes, which have been proposed as a neural basis for encoding probability distributions,...
Biostatistics (Oxford, England)
Oct 13, 2021
A basket trial in oncology encompasses multiple "baskets" that simultaneously assess one treatment in multiple cancer types or subtypes. It is well-recognized that hierarchical modeling methods, which adaptively borrow strength across baskets, can im...
Chaos (Woodbury, N.Y.)
Sep 1, 2021
A quantitative evaluation of the contribution of individual units in producing the collective behavior of a complex network can allow us to understand the potential damage to the structure integrity due to the failure of local nodes. Given a time ser...
Neural computation
Jul 26, 2021
Supervised learning corresponds to minimizing a loss or cost function expressing the differences between model predictions yn and the target values tn given by the training data. In neural networks, this means backpropagating error signals through th...
Proceedings of the National Academy of Sciences of the United States of America
Jul 13, 2021
Forward genetic studies use meiotic mapping to adduce evidence that a particular mutation, normally induced by a germline mutagen, is causative of a particular phenotype. Particularly in small pedigrees, cosegregation of multiple mutations, occasiona...
Science (New York, N.Y.)
Jun 11, 2021
Predicting and understanding how people make decisions has been a long-standing goal in many fields, with quantitative models of human decision-making informing research in both the social sciences and engineering. We show how progress toward this go...
Epidemiology (Cambridge, Mass.)
May 1, 2021
BACKGROUND: Modern causal inference methods allow machine learning to be used to weaken parametric modeling assumptions. However, the use of machine learning may result in complications for inference. Doubly robust cross-fit estimators have been prop...
Biostatistics (Oxford, England)
Apr 10, 2021
The estimated accuracy of a classifier is a random quantity with variability. A common practice in supervised machine learning, is thus to test if the estimated accuracy is significantly better than chance level. This method of signal detection is pa...
Journal of the American Medical Informatics Association : JAMIA
Mar 1, 2021
OBJECTIVE: Due to a complex set of processes involved with the recording of health information in the Electronic Health Records (EHRs), the truthfulness of EHR diagnosis records is questionable. We present a computational approach to estimate the pro...
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Jan 1, 2021
In order to overcome the shortage of the current costly DVT diagnosis and reduce the waste of valuable healthcare resources, we proposed a new diagnostic approach based on machine learning pre-test prediction models using EHRs. We examined the sociod...