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Radiotherapy Planning, Computer-Assisted

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A deep learning-informed interpretation of why and when dose metrics outside the PTV can affect the risk of distant metastasis in SBRT NSCLC patients.

Radiation oncology (London, England)
PURPOSE: Recent papers suggested a correlation between the risk of distant metastasis (DM) and dose outside the PTV, though conclusions in different publications conflicted. This study resolves these conflicts and provides a compelling explanation of...

Deep learning-based segmentation for high-dose-rate brachytherapy in cervical cancer using 3D Prompt-ResUNet.

Physics in medicine and biology
To develop and evaluate a 3D Prompt-ResUNet module that utilized the prompt-based model combined with 3D nnUNet for rapid and consistent autosegmentation of high-risk clinical target volume (HRCTV) and organ at risk (OAR) in high-dose-rate brachyther...

Quantifying and visualising uncertainty in deep learning-based segmentation for radiation therapy treatment planning: What do radiation oncologists and therapists want?

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
BACKGROUND AND PURPOSE: During the ESTRO 2023 physics workshop on "AI for the fully automated radiotherapy treatment chain", the topic of deep learning (DL) segmentation was discussed. Despite its widespread use in radiotherapy, the time needed to ev...

Artificial intelligence (AI) applications in improvement of IMRT and VMAT radiotherapy treatment planning processes: A systematic review.

Radiography (London, England : 1995)
INTRODUCTION: Radiotherapy is a common option in the treatment of many types of cancer. Intensity-Modulated Radiation Therapy (IMRT) and Volumetric-Modulated Arc Therapy (VMAT) are the latest radiotherapy techniques. However, clinicians face problems...

Deep evidential learning for radiotherapy dose prediction.

Computers in biology and medicine
BACKGROUND: As we navigate towards integrating deep learning methods in the real clinic, a safety concern lies in whether and how the model can express its own uncertainty when making predictions. In this work, we present a novel application of an un...

Online Adaptive Proton Therapy Facilitated by Artificial Intelligence-Based Autosegmentation in Pencil Beam Scanning Proton Therapy.

International journal of radiation oncology, biology, physics
PURPOSE: Online adaptive proton therapy (oAPT) is essential to address interfractional anatomical changes in patients receiving pencil beam scanning proton therapy. Artificial intelligence (AI)-based autosegmentation can increase the efficiency and a...

Deep learning-based statistical robustness evaluation of intensity-modulated proton therapy for head and neck cancer.

Physics in medicine and biology
. Previous methods for robustness evaluation rely on dose calculation for a number of uncertainty scenarios, which either fails to provide statistical meaning when the number is too small (e.g., ∼8) or becomes unfeasible in daily clinical practice wh...

Deep learning-based prediction of the dose-volume histograms for volumetric modulated arc therapy of left-sided breast cancer.

Medical physics
BACKGROUND: The advancements in artificial intelligence and computational power have made deep learning an attractive tool for radiotherapy treatment planning. Deep learning has the potential to significantly simplify the trial-and-error process invo...

Artificial intelligence uncertainty quantification in radiotherapy applications - A scoping review.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
BACKGROUND/PURPOSE: The use of artificial intelligence (AI) in radiotherapy (RT) is expanding rapidly. However, there exists a notable lack of clinician trust in AI models, underscoring the need for effective uncertainty quantification (UQ) methods. ...

Nested CNN architecture for three-dimensional dose distribution prediction in tomotherapy for prostate cancer.

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]
BACKGROUND: The hypothesis of changing network layers to increase the accuracy of dose distribution prediction, instead of expanding their dimensions, which requires complex calculations, has been considered in our study.