AIMC Topic: RNA, Neoplasm

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Discovering functional impacts of miRNAs in cancers using a causal deep learning model.

BMC medical genomics
BACKGROUND: Micro-RNAs (miRNAs) play a significant role in regulating gene expression under physiological and pathological conditions such as cancers. However, it remains a challenging problem to discover the target messenger RNAs (mRNAs) of a miRNA ...

CRlncRC: a machine learning-based method for cancer-related long noncoding RNA identification using integrated features.

BMC medical genomics
BACKGROUND: Long noncoding RNAs (lncRNAs) are widely involved in the initiation and development of cancer. Although some computational methods have been proposed to identify cancer-related lncRNAs, there is still a demanding to improve the prediction...

Loss of the integral nuclear envelope protein SUN1 induces alteration of nucleoli.

Nucleus (Austin, Tex.)
A supervised machine learning algorithm, which is qualified for image classification and analyzing similarities, is based on multiple discriminative morphological features that are automatically assembled during the learning processes. The algorithm ...

A graph auto-encoder model for miRNA-disease associations prediction.

Briefings in bioinformatics
Emerging evidence indicates that the abnormal expression of miRNAs involves in the evolution and progression of various human complex diseases. Identifying disease-related miRNAs as new biomarkers can promote the development of disease pathology and ...

Prognostic outcome prediction by semi-supervised least squares classification.

Briefings in bioinformatics
Although great progress has been made in prognostic outcome prediction, small sample size remains a challenge in obtaining accurate and robust classifiers. We proposed the Rescaled linear square Regression based Least Squares Learning (RRLSL), a join...

scCancer: a package for automated processing of single-cell RNA-seq data in cancer.

Briefings in bioinformatics
Molecular heterogeneities and complex microenvironments bring great challenges for cancer diagnosis and treatment. Recent advances in single-cell RNA-sequencing (scRNA-seq) technology make it possible to study cancer cell heterogeneities and microenv...

Machine learning from concept to clinic: reliable detection of BRAF V600E DNA mutations in thyroid nodules using high-dimensional RNA expression data.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
The promise of personalized medicine will require rigorously validated molecular diagnostics developed on minimally invasive, clinically relevant samples. Measurement of DNA mutations is increasingly common in clinical settings but only higher-preval...