AIMC Topic: ROC Curve

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Benchmarking Deep Networks for Predicting Residue-Specific Quality of Individual Protein Models in CASP11.

Scientific reports
Quality assessment of a protein model is to predict the absolute or relative quality of a protein model using computational methods before the native structure is available. Single-model methods only need one model as input and can predict the absolu...

Brain-inspired cheminformatics of drug-target brain interactome, synthesis, and assay of TVP1022 derivatives.

Neuropharmacology
The use of Cheminformatics tools is gaining importance in the field of translational research from Medicinal Chemistry to Neuropharmacology. In particular, we need it for the analysis of chemical information on large datasets of bioactive compounds. ...

Reverse Engineering and Evaluation of Prediction Models for Progression to Type 2 Diabetes: An Application of Machine Learning Using Electronic Health Records.

Journal of diabetes science and technology
BACKGROUND: Application of novel machine learning approaches to electronic health record (EHR) data could provide valuable insights into disease processes. We utilized this approach to build predictive models for progression to prediabetes and type 2...

GIS-based groundwater potential mapping using boosted regression tree, classification and regression tree, and random forest machine learning models in Iran.

Environmental monitoring and assessment
Groundwater is considered one of the most valuable fresh water resources. The main objective of this study was to produce groundwater spring potential maps in the Koohrang Watershed, Chaharmahal-e-Bakhtiari Province, Iran, using three machine learnin...

Characterizing informative sequence descriptors and predicting binding affinities of heterodimeric protein complexes.

BMC bioinformatics
BACKGROUND: Protein-protein interactions (PPIs) are involved in various biological processes, and underlying mechanism of the interactions plays a crucial role in therapeutics and protein engineering. Most machine learning approaches have been develo...

Machine learning to assist risk-of-bias assessments in systematic reviews.

International journal of epidemiology
BACKGROUND: Risk-of-bias assessments are now a standard component of systematic reviews. At present, reviewers need to manually identify relevant parts of research articles for a set of methodological elements that affect the risk of bias, in order t...

A novel approach for analysis of altered gait variability in amyotrophic lateral sclerosis.

Medical & biological engineering & computing
Gait variability reflects important information for the maintenance of human beings' health. For pathological populations, changes in gait variability signal the presence of abnormal motor control strategies. Quantitative analysis of the altered gait...

DisPredict: A Predictor of Disordered Protein Using Optimized RBF Kernel.

PloS one
Intrinsically disordered proteins or, regions perform important biological functions through their dynamic conformations during binding. Thus accurate identification of these disordered regions have significant implications in proper annotation of fu...

Neural hypernetwork approach for pulmonary embolism diagnosis.

BMC research notes
BACKGROUND: Hypernetworks are based on topological simplicial complexes and generalize the concept of two-body relation to many-body relation. Furthermore, Hypernetworks provide a significant generalization of network theory, enabling the integration...