AIMC Topic: Tissue Engineering

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Computational optimization of 3D printed bone scaffolds using orthogonal array-driven FEA and neural network modeling.

Scientific reports
Today, orthopedic surgeons have been continuously focusing on bone tissue engineering for regenerating damaged bone through the use of biomimetic scaffolds and innovative materials. Hence, this study presents a comprehensive investigation into the op...

Non-destructive monitoring of cartilage tissue engineering via near-infrared (NIR) spectroscopic assessment of culture medium.

Biosensors & bioelectronics
Degenerative joint diseases are major contributors to pain, impaired mobility, and an increasing socioeconomic burden in aging populations. Tissue Engineering (TE) offers alternative solutions to restore joint functions. However, current TE approache...

Computer vision to predict cell seeding coverage in re-endothelialized mouse lungs.

Scientific reports
Transplantation of donor grafts recellularized with recipient-derived or non-immunogenic universal cells is a potential means of reducing the graft rejection and post-transplant complications in lung transplantation. Achieving a fully recellularized ...

Decoding tissue complexity: multiscale mapping of chemistry-structure-function relationships through advanced visualization technologies.

Journal of materials chemistry. B
Comprehensively acquiring biological tissue information is pivotal for advancing our understanding of biological systems, elucidating disease mechanisms, and developing innovative clinical strategies. Biological tissues, as nature's archetypal biomat...

Innovations in cancer treatment: evaluating drug resistance with lab-on-a-chip technologies.

International journal of pharmaceutics
Lab-on-a-chip (LoC) technologies have emerged as transformative tools in cancer research, particularly in evaluating drug resistance, which remains a significant barrier to effective treatment. These miniaturized platforms allow for the integration o...

Divide-and-conquer strategy with engineered ossification center organoids for rapid bone healing through developmental cell recruitment.

Nature communications
Current approaches for bone repair predominantly target localized delivery of growth factors that are aimed at the coupling of angiogenesis and osteogenesis. However, delayed revascularization and regeneration of critical-sized bone defects are still...

Discovering novel type I collagen fragments from Cyprinus carpio supporting bone regeneration.

Functional & integrative genomics
Fish collagen is gaining increasing attention in tissue engineering due to its exceptional bioactivity. This study aimed to isolate functional fish collagen fragments capable of microbial biosynthesis and supporting bone tissue regeneration. Collagen...

Biomanufacturing in low Earth orbit: A paradigm shift.

Stem cell reports
This perspective article explores the transformative potential of biomanufacturing in low Earth orbit (LEO) for regenerative medicine. Building on key symposia and workshops, it highlights the International Space Station (ISS) National Laboratory's r...

A soft robotic total artificial hybrid heart.

Nature communications
End-stage heart failure is a deadly disease. Current total artificial hearts (TAHs) carry high mortality and morbidity and offer low quality of life. To overcome current biocompatibility issues, we propose the concept of a soft robotic, hybrid (pumpi...

Measuring alignment of structural proteins in engineered tissue constructs using polarized Raman spectroscopy.

PloS one
Measures of structural protein alignment within biological and engineered tissues are needed for improved understanding of their mechanical behavior and functionality. We advance our method of measuring protein alignment using polarized Raman spectro...