AIMC Topic: Transcriptome

Clear Filters Showing 391 to 400 of 856 articles

Metabonomic and transcriptomic analyses of glycosides tablet-induced hepatotoxicity in rats.

Drug and chemical toxicology May 23, 2022
We aimed to explore novel biomarkers involved in alterations of metabolism and gene expression related to the hepatotoxic effects of glycosides tablet (TGT) in rats. Rats were randomly divided into groups based on oral administration of TGTs for 6 w...
Glycosides Chemical and Drug Induced Liver Injury Tripterygium Rats Biomarkers Liver Animals Drugs, Chinese Herbal Transcriptome Tablets
View on PubMed DOI

Cell cycle gene regulation dynamics revealed by RNA velocity and deep-learning.

Nature communications May 23, 2022
Despite the fact that the cell cycle is a fundamental process of life, a detailed quantitative understanding of gene regulation dynamics throughout the cell cycle is far from complete. Single-cell RNA-sequencing (scRNA-seq) technology gives access to...
Gene Expression Profiling Sequence Analysis, RNA RNA Transcriptome Genes, cdc Deep Learning Single-Cell Analysis
View on PubMed DOI

Identifying common transcriptome signatures of cancer by interpreting deep learning models.

Genome biology May 17, 2022
BACKGROUND: Cancer is a set of diseases characterized by unchecked cell proliferation and invasion of surrounding tissues. The many genes that have been genetically associated with cancer or shown to directly contribute to oncogenesis vary widely bet...
Deep Learning Genomics Gene Expression Regulation, Neoplastic Neoplasms Gene Expression Profiling Transcriptome Humans
View on PubMed DOI

Cross-tissue immune cell analysis reveals tissue-specific features in humans.

Science (New York, N.Y.) May 13, 2022
Despite their crucial role in health and disease, our knowledge of immune cells within human tissues remains limited. We surveyed the immune compartment of 16 tissues from 12 adult donors by single-cell RNA sequencing and VDJ sequencing generating a ...
Humans Single-Cell Analysis Sequence Analysis, RNA B-Lymphocytes Organ Specificity Machine Learning Cells, Cultured T-Lymphocytes Transcriptome
View on PubMed DOI

Gradient tree boosting and network propagation for the identification of pan-cancer survival networks.

STAR protocols Apr 23, 2022
Cancer survival prediction is typically done with uninterpretable machine learning techniques, e.g., gradient tree boosting. Therefore, additional steps are needed to infer biological plausibility of the predictions. Here, we describe a protocol that...
Machine Learning Neoplasms Humans Transcriptome Protein Interaction Maps
View on PubMed DOI

Augmentation of Transcriptomic Data for Improved Classification of Patients with Respiratory Diseases of Viral Origin.

International journal of molecular sciences Feb 24, 2022
To better understand the molecular basis of respiratory diseases of viral origin, high-throughput gene-expression data are frequently taken by means of DNA microarray or RNA-seq technology. Such data can also be useful to classify infected individual...
RNA-Seq Gene Ontology Neural Networks, Computer Machine Learning Humans COVID-19 Reproducibility of Results Algorithms SARS-CoV-2 Gene Expression Profiling Transcriptome
View on PubMed DOI

Combining explainable machine learning, demographic and multi-omic data to inform precision medicine strategies for inflammatory bowel disease.

PloS one Feb 23, 2022
Inflammatory bowel diseases (IBDs), including ulcerative colitis and Crohn's disease, affect several million individuals worldwide. These diseases are heterogeneous at the clinical, immunological and genetic levels and result from complex host and en...
Transcriptome Adolescent Genomics Signal Transduction Colitis, Ulcerative Anti-Inflammatory Agents, Non-Steroidal Humans Young Adult Crohn Disease Naphthalenes Drug Evaluation, Preclinical Machine Learning Adult Pyrazoles Precision Medicine Male Tumor Necrosis Factor-alpha Prednisolone Phenylurea Compounds Female Middle Aged Mesalamine Aged
View on PubMed DOI

Machine Learning Identifies Pan-Cancer Landscape of Nrf2 Oxidative Stress Response Pathway-Related Genes.

Oxidative medicine and cellular longevity Feb 17, 2022
BACKGROUND: Oxidative stress produced a large amount of reactive oxygen species (ROS), which played a pivotal role in balanced ability and determining cell fate. The activated Nrf2 signaling pathway that responds to the excessive ROS regulated the ex...
Neoplasms Humans Transcriptome Machine Learning Case-Control Studies Gene Expression Regulation, Neoplastic Survival Rate Phenotype NF-E2-Related Factor 2 Oxidative Stress Signal Transduction Tumor Microenvironment Prognosis Reactive Oxygen Species Biomarkers, Tumor Mutation Rate
View on PubMed DOI

Construction of genetic classification model for coronary atherosclerosis heart disease using three machine learning methods.

BMC cardiovascular disorders Feb 12, 2022
BACKGROUND: Although the diagnostic method for coronary atherosclerosis heart disease (CAD) is constantly innovated, CAD in the early stage is still missed diagnosis for the absence of any symptoms. The gene expression levels varied during disease de...
Genetic Predisposition to Disease Models, Genetic Support Vector Machine Databases, Genetic Predictive Value of Tests Coronary Artery Disease Machine Learning Phenotype Gene Expression Profiling Transcriptome Humans
View on PubMed DOI

Inferring protein expression changes from mRNA in Alzheimer's dementia using deep neural networks.

Nature communications Feb 3, 2022
Identifying the molecular systems and proteins that modify the progression of Alzheimer's disease and related dementias (ADRD) is central to drug target selection. However, discordance between mRNA and protein abundance, and the scarcity of proteomic...
Aged Aged, 80 and over Male Transcriptome Neural Networks, Computer Brain Female RNA, Messenger Proteomics Proteome Mass Spectrometry Deep Learning Cognitive Dysfunction Dementia RNA-Seq Humans Alzheimer Disease Protein Biosynthesis
View on PubMed DOI
Popular Topics
Recent Journals