Anemia

Navigating the use of artificial intelligence in the peer review process: Cautionary pearls from the editorial board.

Peer review remains a cornerstone of academic publishing, underpinning the integrity and credibility of the scientific literature. High-quality peer review is both a human art and a learned skill, requiring an understanding of study design, critical appraisal and subject-specific expertise. However, the rapid expansion of scientific publishing has placed increasing strain on the peer review ecosys...

Single-cell and bulk transcriptomic profiling of M2-like tumor-associated macrophages reveals a prognostic signature and an inflammation-metabolism crosstalk program in multiple myeloma.

BACKGROUND: M2-like tumor-associated macrophages (TAMs) contribute to multiple myeloma (MM) progression and treatment resistance, yet their internal heterogeneity remains poorly understood. We used single-cell RNA sequencing (scRNA-seq) with bulk transcriptomic cohorts to resolve MM-specific M2-TAM subpopulations and develop a prognostic signature. METHODS: scRNA-seq data from MM and normal bone m...

Risk Factors for Pediatric Acute Chest Syndrome Utilizing Machine Learning Techniques.

Acute chest syndrome (ACS) causes significant morbidity and mortality in both adult and pediatric patients with sickle cell disease (SCD). Despite kno...

AI Dependency and Brain Rot Among Nursing Students: A Mixed-Methods Study.

BACKGROUND: Artificial intelligence (AI) can be beneficial in tailoring learning experiences to each student's learning style, needs, and preferences....

[Paeoniflorin alleviates cancer-related fatigue during chemotherapy for breast cancer by targeting EZH2/CCNE1 to regulate cell cycle and inflammatory microenvironment].

OBJECTIVES: To explore the molecular mechanisms and key pharmacodynamic basis of Baishao for alleviating cancer-related fatigue (CRF) during chemother...

Gut microbiome signatures during acute infection are associated with long COVID.

BACKGROUND: Long COVID (LC) manifests in 10%-30% of non-hospitalized individuals post-SARS-CoV-2 infection, leading to significant morbidity. The pred...

Deep learning-enhanced detection of dental restorations and orthodontic appliances in panoramic radiographs using a clinically annotated dataset.

OBJECTIVE: Manual interpretation of dental panoramic radiographs is labor intensive and prone to diagnostic fatigue, particularly in high-volume setti...

A dissolved oxygen inversion method based on multi-source spectral-spatial feature fusion and recursive feature elimination.

Coastal ecosystem health is crucial for regional sustainability and biodiversity maintenance. As a key indicator of eutrophication and hypoxia risk, t...

Hematopoietic stem cell aging: a review of transcriptional and multi-omics insights and potential paths for AI integration.

Hematopoietic stem cell (HSC) aging underlies age-related immune decline, anemia and increased risk of hematologic malignancies, including clonal hema...

Placenta-derived Exosomes Mitigate Hypoxia-Induced Trophoblast Apoptosis and Inflammatory Progression via SASH1.

SASH1 is a signal adaptor protein involved in cell growth, apoptosis, and immune regulation, and has been increasingly studied in tumor and immune cel...

Foundation Model Forecasting of Headache Days in People With Persisting Postconcussion Symptoms.

OBJECTIVES: We aimed to forecast headache in individuals with persisting postconcussion symptoms using foundation machine learning (ML) models and mul...

Protocol for a pilot effectiveness and feasibility randomized controlled trial of an advanced telerehabilitation system for people with multiple sclerosis (PLATINUMS project).

BACKGROUND: Multiple Sclerosis (MS) causes many different symptoms, with some of the most dominant being impaired balance and walking performance. Exe...

Interpretable Topic Modeling of Spontaneous Speech in Depression Using Large Language Models: Multilingual Four-Cohort Study.

BACKGROUND: Depression is underdiagnosed worldwide, and clinicians rely on interpreting patients' subjective speech. Qualitative analysis of patient l...

Development and validation of a Bayesian network-based surgical risk-prediction tool for patients with small-bowel stricturing Crohn's disease.

BACKGROUND: Patients with small-bowel stricturing Crohn's disease (sbsCD) usually have a higher risk of intestinal surgical resection. We aimed to dev...

Associations of Iron Indicators with Cognitive Impairment Risk in Postmenopausal Women: Evidence from a Matched Case-Control Study and Back Propagation Neural Network Model.

Iron is essential for normal cognitive function, and women have nearly twice the age-matched prevalence of cognitive impairment compared with men. The...

Missed Pulmonary Nodules on CT: Determinants and Implications for Radiologic Practice.

Undetected or unreported lung nodules are a significant cause of failure-to-diagnose errors in radiology. The available literature indicates consisten...

Automated Vocal Fatigue Screening in Professional Voice Users: Development and Occupational Validation of an Automated Assessment System.

INTRODUCTION: Professional voice users face an elevated risk of vocal injury from sustained occupational voice use, yet scalable tools for workplace s...

Single-Atom Nanozymes for High-Efficiency Cancer Immunotherapy by Targeting Tumor Microenvironment.

Tumor immunotherapy has emerged as a transformative strategy for cancer treatment. However, its clinical efficacy remains limited by the immunosuppres...

Explainable machine learning for predicting childhood anemia in Sub-Saharan Africa using population-based DHS Data (2016-2024).

Childhood anemia remains a major public health challenge in Sub-Saharan Africa, adversely affecting physical growth, cognitive development, and child ...

Precision Medicine in Transfusion-Dependent and Non-Transfusion-Dependent β-Thalassemia: Toward Personalized Diagnosis and Therapy.

β-thalassemia comprises a clinically heterogeneous group of disorders in which anemia severity, transfusion exposure, iron loading, and organ complica...