Arthritis

Integrating handheld ultrasound in rheumatology: A review of benefits and drawbacks.

Musculoskeletal ultrasound is a key tool in rheumatology for diagnosing and managing inflammatory arthritis. Traditional ultrasound systems, while effective, can be cumbersome and costly, limiting their use in many clinical settings. Handheld ultrasound (HHUS) devices, which are portable, affordable, and user-friendly, have emerged as a promising alternative. This review explores the role of HHUS ...

Sex differences in serum proteomic profiles in psoriatic arthritis.

OBJECTIVES: Sex-related differences exist in the clinical presentation and treatment outcomes of patients with psoriatic arthritis (PsA). The biological pathways driving these differences remain unknown. We conducted an untargeted proteomic study to identify sex-specific serum proteins and biological pathways in males and females with PsA.

The role of lubrication in function and degeneration of articular cartilage: A critical review and perspectives.

Articular cartilage is a porous, soft tissue present in the synovial joints that distributes the load and lubricate the joint for smooth body movement...

Automated Classification of Rheumatoid Arthritis and Knee Synovitis From Hyperspectral Reflectance Data.

Accurate differentiation between rheumatoid arthritis (RA) and knee synovitis (KS) is essential for guiding optimal treatment, yet conventional histop...

Fully automated workflow for designing patient-specific orthopaedic implants: Application to total knee arthroplasty.

Background Osteoarthritis affects about 528 million people worldwide, causing pain and stiffness in the joints. Arthroplasty is commonly performed to ...

Prediction of Medial Tibiofemoral Joint Reaction Force Using Custom Instrumented Insoles and Neural Networks for Walking and Running Tasks.

Medial tibiofemoral joint reaction force is a clinically relevant variable for knee osteoarthritis progression and can be estimated using complex musc...

An effective statistical moment-based feature extraction technique to identify the phosphoglycerylation sites from protein sequences.

A kind of covalent modification known as post-translational modification (PTM) happens following the biosynthesis process, which is important in cell ...

Development and evaluation of a multivariable prediction model for clinical improvement in an established cohort of Colombian rheumatoid arthritis patients.

BACKGROUND: Rheumatoid arthritis (RA) is a chronic autoimmune disease, and a predicting clinical improvement is essential.

Melioidosis molecular diagnostics: An update.

Melioidosis, a fatal tropical disease, presents a wide array of clinical manifestations, including abscesses, pneumonia, septic shock, bacteraemia, os...

Semantic Search of FDA Guidance Documents Using Generative AI.

INTRODUCTION: Generative artificial intelligence (AI) has the potential to transform and accelerate how information is accessed during the regulation ...

Global variations in artificial intelligence-generated information on juvenile idiopathic arthritis.

OBJECTIVES: We aimed to evaluate similarities and variations of information provided by Large Language Models (LLMs) across diverse world regions by a...

Spatiotemporal distributions and regional disparities of rheumatoid arthritis in 953 global to local locations, 1980-2040, with deep learning-empowered forecasts and evaluation of interventional policies' benefits.

OBJECTIVES: To investigate global to local socioeconomic-driven distributions and inequalities in burdens of rheumatoid arthritis (RA) and to forecast...

The Role of Artificial Intelligence Large Language Models in Personalized Rehabilitation Programs for Knee Osteoarthritis: An Observational Study.

BACKGROUND: Large language models (LLMs) can contribute to treatment options and outcomes by assisting physiotherapists for conditions like osteoarthr...

Integrated bioinformatics and network pharmacology to identify and validate macrophage polarization related hub genes in the treatment of osteoarthritis with Astragalus membranaceus.

BACKGROUND: Macrophage polarization exacerbates the pathological processes of osteoarthritis (OA). Astragalus membranaceus (AM) can repair chondrocyte...

Identification and validation of aging related genes in osteoarthritis.

BACKGROUND: Osteoarthritis (OA) is a degenerative disease associated with aging. Although an increasing body of research suggests a close relationship...

To explore the molecular mechanisms and shared genetic characteristics of rheumatoid arthritis and cervical cancer based on multiple omics and clinical samples.

OBJECTIVE: The potential association between rheumatoid arthritis (RA) and cervical cancer risk is still debated and necessitates additional clinical ...

Development of a machine learning-based predictive nomogram for screening children with juvenile idiopathic arthritis: a pseudo-longitudinal study of 223,195 children in the United States.

BACKGROUND: Juvenile idiopathic arthritis (JIA) is a prevalent chronic rheumatological condition in children, with reported prevalence ranging from 12...

Exploring the genetic characteristics of overweight-related osteoarthritis using machine learning.

This investigation employed a synergistic approach integrating bioinformatics and machine learning methodologies to scrutinize overweight-related oste...

An AI system for continuous knee osteoarthritis severity grading: An anomaly detection inspired approach with few labels.

The diagnostic accuracy and subjectivity of existing Knee Osteoarthritis (OA) ordinal grading systems has been a subject of on-going debate and concer...

AI in Orthopedic Research: A Comprehensive Review.

Artificial intelligence (AI) is revolutionizing orthopedic research and clinical practice by enhancing diagnostic accuracy, optimizing treatment strat...