Neurology

Autism

Latest AI and machine learning research in autism for healthcare professionals.

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Using AI to enhance healthcare resource management and allocation: A focus on the autism community in Alabama.

This study investigates the potential of artificial intelligence, particularly Natural Language Processing and large-scale language models, to improve resource management and service access for individuals with autism in Alabama. The research aims to explore and evaluate the potential of AI-driven tools to address challenges in navigating complex datasets and supporting social work practices. We d...

Mar 16 2026 41838731

Temporal and Cell-Specific Regulation of Synaptic Homeostasis by the Chromatin Remodeler Chd1.

Disruptions in chromatin remodelers and synaptic proteins represent major genetic risk factors for autism spectrum disorder (ASD), yet how these distinct gene classes converge to impair circuit function remains unclear. CHD2, a chromatin remodeler linked to ASD, epilepsy, and intellectual disability, regulates gene expression through epigenetic mechanisms. In Drosophila, its homologue Chd1 functio...

Mar 15 2026 41833011
Epilepsy: Modern Treatment Approaches, Clinical Aspects, and Patent Status.

Epilepsy is a chronic neurological disorder causing recurrent seizures. Improved diagnosis and management, including high-resolution imaging, genetic ...

Mar 13 2026 41833030
Machine learning-based proteogenomic data modeling identifies circulating plasma biomarkers for early detection of lung cancer.

BACKGROUND: Genetic aberrations are among the critical driving factors of lung cancer. Importantly, the impact of genetic variations on proteomic dysr...

Mar 13 2026 41826692
The promise of biomarkers in Psoriatic Arthritis: Moving towards precision medicine.

Psoriatic arthritis is a heterogeneous disease where delayed diagnosis and variable treatment responses remain significant challenges. This review add...

Mar 13 2026 41832134
Biosignatures of cognitive basic symptoms mark a distinct neurodevelopmental pathway to schizophrenia.

Efforts to predict schizophrenia risk using biological data have been hampered by the heterogeneity of current "clinical-high-risk" (CHR-P) criteria, ...

Mar 13 2026 41823413
Genetic and clinical determinants of tacrolimus accumulation in early liver transplantation: evidence for a combined genotype-antibiotic effect.

BACKGROUND: Tacrolimus is a first-line immunosuppressant essential for preventing graft rejection after liver transplantation, but its narrow therapeu...

Mar 12 2026 41821195
Olfactomedin 1 acts as a tumor suppressor in glioblastoma: integrated analysis and mechanistic prediction.

Glioblastoma (GBM) is an aggressive brain tumor with a poor prognosis, yet its molecular mechanisms remain incompletely understood. Olfactomedin 1 (OL...

Mar 12 2026 41831591
Tissue-resolved molecular landscape reveals hepatic regulatory networks and metabolic mediators underlying feed efficiency in chickens.

INTRODUCTION: Residual feed intake (RFI) is a key indicator of feed efficiency in poultry and is regulated by coordinated physiological processes acro...

Mar 12 2026 41831681
Sleep awake detection from leg-worn wearables using deep sensor fusion.

Restful sleep is essential for health, yet many children with Attention Deficit Hyperactivity Disorder (ADHD) experience disturbances such as delayed ...

Mar 12 2026 41820476
BRAF inhibitor resistance in melanoma: from resistance mechanisms to therapeutic innovations.

BRAF inhibitors (BRAFi) have transformed the treatment of BRAF mutant melanoma, but inherent and acquired resistance remains a major barrier to curati...

Mar 11 2026 41807883
Silent Signals: The Expanding Role of Cell-Free DNA in Women's Health, Pregnancy, and Reproductive Medicine.

Cell-free DNA (cfDNA) is an emerging biomarker detectable in various bodily fluids, with promising implications across a wide range of clinical domain...

Mar 11 2026 41813599
Optimizing Diagnostic Accuracy of Clinical Red Flags in RASopathies.

RASopathies are a group of genetic disorders caused by pathogenic variants in the RAS-mitogen-activated protein kinase (RAS-MAPK) signaling pathway, o...

Mar 11 2026 41813603
HIF3A-mediated aberrant activation of TXNIP promotes Alzheimer's disease progression.

Oxidative stress (OS) is a hallmark of Alzheimer's disease (AD), yet the cell type-specific mechanisms remain unclear. We analyzed a single-cell RNA s...

Mar 10 2026 41807716
Pediatric SleepNet: A Deep Learning Network for Reliable Pediatric Sleep Staging Across Developmental Stages.

STUDY OBJECTIVES: Manual sleep staging in pediatric populations is challenging due to developmental variability and limited scoring consistency, espec...

Mar 10 2026 41804802
Machine learning approaches to identifying neurodevelopmental disorders using social media data: a systematic review.

BACKGROUND: Neurodevelopmental disorders (NDDs), such as autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD), often eme...

Mar 7 2026 41812463
Neuroimaging insights into the neurophysiological subtypes of major depressive disorder.

Major depressive disorder (MDD) is a highly heterogeneous condition that limits the reliability of symptom-based diagnosis and treatment selection. In...

Mar 5 2026 41794061
Clinical application progress and prospects of non-invasive preimplantation genetic testing (niPGT): A review.

Preimplantation genetic testing (PGT) is a critical tool in reproductive medicine for selecting genetically healthy embryos, thereby reducing the risk...

Mar 5 2026 41794367
Automated interpretable artificial intelligence genomic prediction with AIGP.

Predicting phenotypes from genomic mutations remains a major genetic challenge. Traditional statistical methods (such as GBLUP and BayesR) have limita...

Mar 5 2026 41786603
Functional Data Strengthen Clinical Validation of PhenoScore Phenotype-Guided AI for ANKRD11 Missense Variants.

KBG syndrome (KBGS, OMIM #148050) is a rare genetic disorder caused by heterozygous truncating or missense variants in the ANKRD11 gene or a deletion ...

Mar 5 2026 41786677
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