Autism

Neuron-Inspired Ferroelectric Bioelectronics for Adaptive Biointerfacing.

Implantable bioelectronics, which are essential to neuroscience studies, neurological disorder treatment, and brain-machine interfaces, have become indispensable communication bridges between biological systems and the external world through sensing, monitoring, or manipulating bioelectrical signals. However, conventional implantable bioelectronic devices face key challenges in adaptive interfacin...

Comprehensive duck DNA fingerprinting based on machine learning for breed identification.

Duck is one of the most widely distributed waterfowl in the world, with more than 6 billion of them farmed annually in the world, and has great economic and ecological value. Amidst mounting global prioritization of duck genetic resource exploration and prevalent inter-varietal hybridization events, the traditional breed identification methods are difficult to address actual requirements, restrict...

Development and Validation of Machine Learning-Based Marker for Early Detection and Prognosis Stratification of Nonalcoholic Fatty Liver Disease.

Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease and is considered the hepatic manifestation of metabolic syndro...

Multiscale Organization of Neural Networks in a 3D Bioprinted Matrix.

The efficient establishment of in vitro neural models that accurately mimic the structural and functional connectivity of neural networks is critical ...

Genomic advancements in goat breeding: enhancing productivity, disease resistance, and sustainability in India's rural economy.

Goats are vital to the rural economy of India, contributing significantly to livelihoods, nutrition, and agricultural sustainability. With a populatio...

Prediction of treatment efficacy in the suanzaoren decoction and estazolam for chronic insomnia disorder, along with brain function and cognitive changes before and after treatment, and potential gene expression profiles.

OBJECTIVE: This study compared the brain function changes in chronic insomnia disorder (CID) before and after treatment by suanzaoren decoction (SZRD)...

Hypertension precision medicine: the promise and pitfalls of pharmacogenomics.

Pharmacogenomics (PGx) has the potential to revolutionize hypertension management by tailoring antihypertensive therapy based on genetic profiles. Des...

Modeling Brain Aging with Explainable Triamese ViT: Towards Deeper Insights into Autism Disorder.

Machine learning, particularly through advanced imaging techniques such as three-dimensional Magnetic Resonance Imaging (MRI), has significantly impro...

Optimizing phage therapy with artificial intelligence: a perspective.

Phage therapy is emerging as a promising strategy against the growing threat of antimicrobial resistance, yet phage and bacteria are incredibly divers...

SLC35A2 loss-of-function variants affect glycomic signatures, neuronal fate and network dynamics.

SLC35A2 encodes a UDP-galactose transporter essential for glycosylation of proteins and galactosylation of lipids and glycosaminoglycans. Germline gen...

Large-scale examination of early-age sex differences in neurotypical toddlers and those with autism spectrum disorder or other developmental conditions.

Autism spectrum disorder (ASD) is clinically heterogeneous, with ongoing debates about phenotypic differences between boys and girls. Understanding th...

Computational Risk Stratification of Preclinical Alzheimer's in Younger Adults.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that often begins decades before clinical symptoms manifest. Early detection rem...

Sex-related differences and associated transcriptional signatures in the brain ventricular system and cerebrospinal fluid development in full-term neonates.

BACKGROUND: The cerebrospinal fluid (CSF) is known to serve as a unique environment for neurodevelopment, with specific proteins secreted by epithelia...

Deep learning algorithms reveal genomic markers for anxiety disorder in a large cohort of children with down syndrome.

Despite a significant burden of neurobehavioral and psychiatric comorbidities in children with Down syndrome (DS), and the general increased risk for ...

Deconstructing the GWAS library - Next Generation GWAS.

Genome-wide association studies (GWAS) have identified numerous common genetic variants associated with cardiovascular traits and diseases. These stud...

Biallelic loss-of-function variants in ZNF142 are associated with a robust DNA methylation signature affecting a limited number of genomic loci.

Biallelic inactivating variants in ZNF142 underlie a clinically variable neurodevelopmental disorder. ZNF142 is a zinc-finger transcription factor wit...

Integrating Knowledge: The Power of Ontologies in Psychiatric Research and Clinical Informatics.

Ontologies are structured frameworks for representing knowledge by systematically defining concepts, categories, and their relationships. While widely...

Towards precision medicine in antiphospholipid syndrome.

Antiphospholipid syndrome is a rare systemic autoimmune disorder with complex pathophysiology and high heterogeneity in clinical presentation and trea...

Optimizing Treatment for Depression in Primary Care Using Psychotherapy Versus Antidepressant Medication in a Low-Resource Setting: Protocol for the OptimizeD Randomized Controlled Trial.

Psychotherapy and antidepressant medications are first-line treatments for depression, and they both have significant treatment effects on average. H...

The Gut Microbiota in Young Adults with High-Functioning Autism Spectrum Disorder and Its Performance as Diagnostic Biomarkers.

Diagnosing ASD in adults presents unique challenges, and there are currently no specific biomarkers for this condition. Most existing studies on the ...