Bacterial Infection

Detection of carbapenem-resistant Klebsiella pneumoniae on the basis of matrix-assisted laser desorption ionization time-of-flight mass spectrometry by using supervised machine learning approach.

BACKGROUND: Carbapenem-resistant Klebsiella pneumoniae (CRKP) is emerging as a significant pathogen causing healthcare-associated infections. Matrix-assisted laser desorption/ionisation mass spectrometry time-of-flight mass spectrometry (MALDI-TOF MS) is used by clinical microbiology laboratories to address the need for rapid, cost-effective and accurate identification of microorganisms. We evalua...

Computer-Aided Design of Antimicrobial Peptides: Are We Generating Effective Drug Candidates?

Antimicrobial peptides (AMPs), especially antibacterial peptides, have been widely investigated as potential alternatives to antibiotic-based therapies. Indeed, naturally occurring and synthetic AMPs have shown promising results against a series of clinically relevant bacteria. Even so, this class of antimicrobials has continuously failed clinical trials at some point, highlighting the importance ...

Rapid Detection From Clinical Mastitis Milk by Colloidal Gold Nanoparticle-Based Immunochromatographic Strips.

Rapid diagnostic technologies for bovine mastitis caused by () are urgently needed. In the current study, we generated an anti-ribosomal protein-L7/L...

Promotes Stable Polymicrobial Biofilms With the Major Otopathogens.

Otitis media (OM) is a prevalent pediatric infection characterized by painful inflammation of the middle ear. The Gram-negative diplococcus is a comm...

Digging Deeper to Save the Old Anti-tuberculosis Target: D-Alanine-D-Alanine Ligase With a Novel Inhibitor, IMB-0283.

The emergence of drug-resistant (Mtb) has hampered treatments for tuberculosis, which consequently now require novel agents to overcome such drug res...

Fluorescent Sensor Arrays Can Predict and Quantify the Composition of Multicomponent Bacterial Samples.

Fast and reliable identification of infectious disease agents is among the most important challenges for the healthcare system. The discrimination of ...

VAMPr: VAriant Mapping and Prediction of antibiotic resistance via explainable features and machine learning.

Antimicrobial resistance (AMR) is an increasing threat to public health. Current methods of determining AMR rely on inefficient phenotypic approaches,...

Comprehensive analysis of rule formalisms to represent clinical guidelines: Selection criteria and case study on antibiotic clinical guidelines.

BACKGROUND: The over-use of antibiotics in clinical domains is causing an alarming increase in bacterial resistance, thus endangering their effectiven...

Self-assembled natural phytochemicals for synergistically antibacterial application from the enlightenment of traditional Chinese medicine combination.

The application of nanotechnology for antimicrobial delivery has capacity to improve antibacterial efficacy. Currently, the usage of various inorganic...

Fate of pirlimycin and antibiotic resistance genes in dairy manure slurries in response to temperature and pH adjustment.

Quantifying the fate of antibiotics and antibiotic resistance genes (ARGs) in response to physicochemical factors during storage of manure slurries wi...

Protective effect of bacterial lipase on lipopolysaccharide-induced toxicity in rat cardiomyocytes; H9C2 cell line.

Cardiovascular system is highly sensitive to LPS-induced oxidative damage. This study aimed to show the inhibitory effect of bacterial Lipase on LPS-...

Inhibitory effect of ethanol and thiamine dilaurylsulfate against loosely, intermediately, and tightly attached mesophilic aerobic bacteria, coliforms, and Salmonella Typhimurium in chicken skin.

The effects of 3 ethanol levels (30, 50, and 70%) with and without thiamine dilaurylsulfate (TDS; 1,000 ppm) were evaluated for the reduction of natur...

Covalent Functionalization of Graphene Sheets with Different Moieties and Their Effects on Biological Activities.

The ongoing spread of multi-drug-resistant bacteria over the past few decades necessitates collateral efforts to develop new classes of antibacterial ...

Antimicrobial activities of against selected pathogenic fungi and bacteria strains.

and are dangerous pathogens causing fungal diseases. and developed resistance to fungicides such as fluconazole. Similarly, pathogenic bacteria h...

Detecting antimicrobial peptides by exploring the mutual information of their sequences.

The rise of antibiotic resistance in pathogenic bacteria is a growing concern for every part of the world. The present study shows the prediction effi...

Self-Assembled Polyurethane Capsules with Selective Antimicrobial Activity against Gram-Negative .

This article reports the antimicrobial activity of two segmented amphiphilic polyurethanes, PU-1 and PU-2, containing a primary or secondary amine gro...

Antioxidant capacity, antimicrobial activities and chemical composition of subsp essential oil.

This study aimed to evaluate the composition, antioxidant capacity and antibacterial effects of subsp. (baneh) essential oil on some important bacte...

Research Note: Longitudinal monitoring of chicken houses in a commercial layer farm for antimicrobial resistance in Escherichia coli with special reference to plasmid-mediated quinolone resistance.

Plasmid-mediated quinolone resistance (PMQR) genes located on conjugative plasmids can be transferred to other bacteria in the absence of antimicrobia...

Kinetics Analysis and Susceptibility Coefficient of the Pathogenic Bacteria by Titanium Dioxide and Zinc Oxide Nanoparticles.

The increase of bacterial resistance to common antibacterial agents is one of the major problems of health care systems and hospital infection contro...

A Machine Learning-Based Raman Spectroscopic Assay for the Identification of and Related Species.

, the causative agent of glanders, and , the causative agent of melioidosis in humans and animals, are genetically closely related. The high infectiou...