Chemotherapy

Mitochondrial dysfunction and cell death induced by Toona sinensis leaf extracts through MEK/ERK signaling in glioblastoma cells.

Toona sinensis, a kind of phytochemicals in traditional Chinese medicine widely used in South-East Asia, has been recognized for its anticancer properties, particularly against various types of cancer. We aimed to evaluate the effectiveness of T. sinensis leaf extracts (TSL) specifically for glioblastoma multiforme (GBM). Gallic acid was identified as the major active component in the aqueous extr...

Arylacetamides exhibit antiproliferative effects on non-transformed mammalian and vegetal cells and toxicity on crustaceans and fish embryos.

Non-clinical steps for development, validation and biosafety of new medicines and products comprises studies on cells, proteins, and animals. Herein, we evaluated the toxic activity of antitumoral 2-chloro--arylacetamides on eukaryotic dividing cells and animal replacement models. Firstly, the cytotoxicity of chloro (compound ), bromo (compound ) and nitro (compound ) acetamides was analyzed by fl...

Promethazine for nausea and vomiting prevention after gynaecological laparoscopic surgery: A randomized controlled trial.

Postoperative nausea and vomiting (PONV) represent significant concerns for patients undergoing surgical procedures, as these symptoms greatly impact ...

Isolation and characterization of a bioactive compound from Sphingomonas sanguinis DM with cytotoxic and molecular docking analysis.

Datura metel, a common plant in the Solanaceae family, is known for its valuable medicinal properties. The metabolites created by its rhizosphere bact...

Interferon gamma-induced hub genes and key pathways: A study based on biological network analysis and experimental validation.

By performing a biological network analysis, we identified some hub genes, which were up- or down-regulated in the breast cancer (BC) cell line after ...

Leafing a mark on immunity: Quercetin-3-O-D-glucopyranoside and quercetin-3-O-(2″,6″-digalloyl)-β-D-galactopyranoside-rich Melia azedarach L. extract's immunoinflammatory effects on an sRBC-immunized BALB/c model.

Melia azedarach L. (Meliaceae) (MA) leaves are traditionally used for inflammatory disorders, yet their immunomodulatory effects on lymphocytes remain...

Correction to "The Melamine-Driven Solvation Effect Promotes Oxygen Reduction on Platinum Catalyst: Machine Learning-Aided Free Energy Calculations".

Stacking classifiers based on integrated machine learning model: fusion of CT radiomics and clinical biomarkers to predict lymph node metastasis in locally advanced gastric cancer patients after neoadjuvant chemotherapy.

BACKGROUND: The early prediction of lymph node positivity (LN+) after neoadjuvant chemotherapy (NAC) is crucial for optimizing individualized treatmen...

Identification of Npas4 as a biomarker for CICI by transcriptomics combined with bioinformatics and machine learning approaches.

Chemotherapy is one of the most successful strategies for treating cancer. Unfortunately, up to 70 % of cancer survivors develop cognitive impairment ...

An efficient patient's response predicting system using multi-scale dilated ensemble network framework with optimization strategy.

The forecasting of a patient's response to radiotherapy and the likelihood of experiencing harmful long-term health impacts would considerably enhance...

Evaluation of Artificial Intelligence Models for Nutritional Symptom Management in Breast Cancer Patients Undergoing Chemotherapy.

The purpose of the study is to determine if artificial intelligence (AI) models could provide dietary recommendations to manage chemotherapy-induced n...

Artificial intelligence-based muscle analysis risk assessment of treatment-related toxicity in metastatic colorectal cancer.

IntroductionUp to 60% of adults with metastatic colorectal cancer (mCRC) receiving combination cytotoxic chemotherapy may experience loss of skeletal ...

Training, Validating, and Testing Machine Learning Prediction Models for Endometrial Cancer Recurrence.

PURPOSE: Endometrial cancer (EC) is the most common gynecologic cancer in the United States with rising incidence and mortality. Despite optimal treat...

Forecasting optimal treatments in relapsed/refractory mature T- and NK-cell lymphomas: A global PETAL Consortium study.

There is no standard of care in relapsed/refractory T-cell/natural killer-cell lymphomas. Patients often cycle through cytotoxic chemotherapy (CC), ep...

Tumor grade-titude: XGBoost radiomics paves the way for RCC classification.

This study aimed to develop and evaluate a non-invasive XGBoost-based machine learning model using radiomic features extracted from pre-treatment CT i...

Detection of pathologic complete response using deep neural network-based endoscopic evaluation in patients with esophageal cancer receiving neoadjuvant chemotherapy: a nationwide multicenter retrospective study from 46 Japanese esophageal centers.

BACKGROUND: Detecting pathological complete response (pCR) preoperatively facilitated a non-surgical approach after neoadjuvant chemotherapy (NAC). We...

Development and validation of an interpretable machine learning model for diagnosing pathologic complete response in breast cancer.

BACKGROUND: Pathologic complete response (pCR) following neoadjuvant chemotherapy (NACT) is a critical prognostic marker for patients with breast canc...

Machine learning modeling and response surface methodology driven antioxidant and anticancer activities of chitosan nanoparticle-mediated extracts of Bacopa monnieri.

This study investigates the potential of chitosan nanoparticles (CNPs) in enhancing the bioavailability and efficacy of Bacopa monnieri extracts, know...

The association of trimethylamine N-oxide with diabetic retinopathy Pathology: Insights from network toxicology and molecular docking analysis.

Trimethylamine N-oxide (TMAO), a gut microbiota-derived metabolite, has emerged as a potential contributor to diabetic retinopathy (DR) progression. H...

Inhibiting Dissolution of Platinum with Atomic Rare Earth Bridged by Nitrogen to Boost Alkaline Hydrogen Evolution.

The unfavorable water dissociation and continuous dissolution of Pt single-atom catalysts significantly impede their practical application in alkaline...