Oncology/Hematology

Chemotherapy

Latest AI and machine learning research in chemotherapy for healthcare professionals.

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Cytotoxic and Antimicrobial Constituents from the Essential Oil of Lippia alba (Verbenaceae).

(Verbenaceae) is a plant widely used in folk medicine to treat various diseases. The present work deals with the chemical composition of the crude essential oil extracted from leaves of and evaluation of its antimicrobial and cytotoxic activities. Leaves of were extracted by hydrodistillation and analyzed by gas chromatography/mass spectrometry (GC/MS) as well as by nuclear magnetic resonance ...

Aug 12 2016 28930132

Neuro-endocrine effects of aqueous extract of (Linn.) leaf in male Wistar rat model of cyclophosphamide-induced reproductive toxicity.

Cyclophosphamide (CP) is a widely used cytotoxic alkylating agent with antitumor and immunosuppressant properties that is associated with various forms of reproductive toxicity. The significance of natural antioxidants of plant origin should be explored, especially in a world with increasing incidence of patients in need of chemotherapy. The neuro-endocrine effects of aqueous extract of (Linn.) l...

Aug 3 2016 28959584
An approach for deciphering patient-specific variations with application to breast cancer molecular expression profiles.

Several studies have successfully used molecular expression profiling in conjunction with classification techniques for discerning distinct disease gr...

Jul 28 2016 27477838
Fabrication of an electrochemical sensor for determination of doxorubicin in human plasma and its interaction with DNA.

In this work, an electrochemical sensor was fabricated for determination of an anthracycline, doxorubicin (DOX) as a chemotherapy drug in plasma based...

Jul 19 2016 29404015
Glutathione Disulfide Liposomes - a Research Tool for the Study of Glutathione Disulfide Associated Functions and Dysfunctions.

Glutathione disulfide (GSSG) is the oxidized form of glutathione (GSH). GSH is a tripeptide present in the biological system in mM concentration and i...

Jun 28 2016 28409182
Hybrid-Actuating Macrophage-Based Microrobots for Active Cancer Therapy.

Using macrophage recruitment in tumors, we develop active, transportable, cancer theragnostic macrophage-based microrobots as vector to deliver therap...

Jun 27 2016 27346486
Ontology-based collection, representation and analysis of drug-associated neuropathy adverse events.

BACKGROUND: Neuropathy often occurs following drug treatment such as chemotherapy. Severe instances of neuropathy can result in cessation of life-savi...

May 21 2016 27213033
Simultaneous determination of nine bioactive compounds in Yijin-tang via high-performance liquid chromatography and liquid chromatography-electrospray ionization-mass spectrometry.

BACKGROUND: Yijin-tang (YJ) has been used traditionally for the treatment of cardiovascular conditions, nausea, vomiting, gastroduodenal ulcers, and c...

Apr 13 2016 28462109
Protective effect of ginsenosides Rk3 and Rh4 on cisplatin-induced acute kidney injury and .

BACKGROUND: Nephrotoxicity is the major side effect in cisplatin chemotherapy. Previously, we reported that the ginsenosides Rk3 and Rh4 reduced cispl...

Apr 6 2016 28701862
Efficacy of Upper Extremity Robotic Therapy in Subacute Poststroke Hemiplegia: An Exploratory Randomized Trial.

BACKGROUND AND PURPOSE: Our aim was to study the efficacy of robotic therapy as an adjuvant to standard therapy during poststroke rehabilitation.

Mar 22 2016 27006452
SNRFCB: sub-network based random forest classifier for predicting chemotherapy benefit on survival for cancer treatment.

Adjuvant chemotherapy (CTX) should be individualized to provide potential survival benefit and avoid potential harm to cancer patients. Our goal was t...

Feb 11 2016 26864276
Phenolic acid content, antioxidant and cytotoxic activities of four species.

Phenolic acid composition, antioxidant, and cytotoxic activities in leaves of four (Crassulaceae) species were evaluated. Determination of phenolic a...

Feb 1 2016 29740226
Extreme effects of Seabuckthorn extracts on influenza viruses and human cancer cells and correlation between flavonol glycosides and biological activities of extracts.

Seabuckthorn is a medicinal plant that is used to prevent cold. It was tested for its metabolic content followed by activity against cancer and virus....

Jan 7 2016 30294231
Garlic ((Allium sativum)) Fresh Juice Induces Apoptosis in Human Oral Squamous Cell Carcinoma: The Involvement of Caspase-3, Bax and Bcl-2.

Background and aims. There is no report on the apoptotic impact of Allium sativum L.(Garlic) on the oral squamous cell carcinoma (KB); hence, this stu...

Dec 30 2015 26889365
Antibacterial and Cytotoxic Activity of Compounds Isolated from Flourensia oolepis.

The antibacterial and cytotoxic effects of metabolites isolated from an antibacterial extract of Flourensia oolepis were evaluated. Bioguided fraction...

Dec 27 2015 26819623
O-naphthoquinone isolated from Capraria biflora L. induces selective cytotoxicity in tumor cell lines.

Biflorin is an o-naphthoquinone isolated from the roots of the plant Capraria biflora L. (Scrophulariaceae). In this study, the cytotoxic effects of b...

Dec 21 2015 26782390
Preparation, characterization and toxicological investigation of copper loaded chitosan nanoparticles in human embryonic kidney HEK-293 cells.

Metallic nanoparticles often attribute severe adverse effects to the various organs or tissues at the molecular level despite of their applications in...

Dec 18 2015 26838845
Adjuvant Carboplatin Treatment in 115 Patients With Stage I Seminoma: Retrospective Multicenter Survey.

BACKGROUND: The administration of carboplatin AUC 7 has become a standard adjuvant option for patients undergoing orchiectomy for stage I seminoma, in...

Dec 17 2015 26775721
The Role of Endophytic Fungi in the Anticancer Activity of Morinda citrifolia Linn. (Noni).

We hypothesize that the fungal endophytes of noni may possibly play a role in its overall pharmacological repertoire, especially since the perceived e...

Dec 10 2015 26783408
Image Guided Hypofractionated Postprostatectomy Intensity Modulated Radiation Therapy for Prostate Cancer.

PURPOSE: Hypofractionated radiation therapy (RT) has promising long-term biochemical relapse-free survival (bRFS) with comparable toxicity for definit...

Dec 2 2015 26867889
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