Infectious Disease

COVID-19

Latest AI and machine learning research in covid-19 for healthcare professionals.

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Autonomous Liquid-handling Robotics Scripting for Accessible and Responsible Protein Engineering

Laboratory automation enhances experimental throughput and reproducibility, yet widespread adoption ...

ProAffinity++

Proteins are essential biological macromolecules that play a crucial role in living organisms. Prote...

HyperBind2: Multi-Shot Learning Enables Progressive Improvement in Computational Antibody Discovery

Antibody discovery remains constrained by resource-intensive experimental screening approaches that ...

Rubisco is slow across the tree of life

Rubisco is the main gateway through which inorganic carbon enters the biosphere, catalyzing the vast...

Predicting and Designing Red Fluorescent Protein Variants Using Sequence-to-Function Machine Learning Models

Fluorescent proteins (FPs) are widely used reporters for visualizing cellular structures and process...

Sequence and structural determinants of efficacious de novo chimeric antigen receptors

Advances in generative protein design using artificial intelligence (AI) have enabled the rapid deve...

Fitness Landscape for Antibodies 2: Benchmarking Reveals That Protein AI Models Cannot Yet Consistently Predict Developability Properties

A prominent application of machine learning in therapeutic antibody design is the development of mod...

AlphaRING-X: accurate interpretation of missense variant deleteriousness based on protein structural stability

Accurate interpretation of missense variants remains a significant challenge hindering genomic diagn...

Social isolation upregulates takeout expression in female Drosophila melanogaster to promote sucrose feeding

Drosophila melanogaster provides a model system to examine how environmental stress interacts with s...

DeepRank-Ab: a scoring function for antibody-antigen complexes based on geometric deep learning

Gaining structural insights into the interactions between antibodies and their corresponding antigen...

Analyzing associations and higher-order effects in multi-omics data with double machine learning

Integrative omics analyses enhance our understanding of disease mechanisms and biomarkers by investi...

Structure and evolution-guided design of minimal RNA-guided nucleases

The design of RNA-guided nucleases with properties not limited by evolution can expand programmable ...

Integrative multiomic analysis on single-nucleotide variants identifies candidate genes for human craniofacial malformation

Craniofacial malformation (CFM) is a congenital defect encompassing a wide range of phenotypic prese...

Microenvironment-Inferred Genotyping: An Exclusionary Classifier for EGFR Amplification When DNA Testing Fails

EGFR amplification occurs in approximately 40-50% of glioblastoma (GBM) cases and is critical for tr...

Multi-modal, multi-species, and multi-task latent-space model for decoding level of consciousness

Assessing the degree and characteristics of consciousness is central to caring for patients with Dis...

MeLSI: Metric Learning for Statistical Inference in Microbiome Community Composition Analysis

Microbiome beta diversity analysis relies on distance-based methods including PERMANOVA combined wit...

Integrative Genomic and Functional Analyses Reveal NINL as a Modulator of Tau Aggregation

Proteostasis dysfunction is a hallmark of frontotemporal dementia (FTD) and Alzheimer’s disease (AD)...

Combinatorial Protein Language Model–Guided Engineering of TEV Protease for Enhanced Stability and Production

Industrial enzyme engineering focuses on improvement of enzyme production yield, stability, catalyti...

FMAGJ: Fluorescence Microscopic Astrocyte Gap Junction Images Dataset

This work introduces a novel and specialized dataset of high-resolution fluorescence microscopic ima...

Ω-Loop mutations control dynamics of the active site by modulating the hydrogen-bonding network in PDC-3 β-lactamase

The expression of antibiotic-inactivating enzymes, such as Pseudomonas-derived cephalosporinase-3 (P...

Sparse, random sampling is sufficient for central tolerance

Negative selection in the thymus limits autoimmunity by eliminating T cells that react strongly to s...

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