FDA General

Regulatory Approval versus Clinical Validation of Artificial Intelligence Diagnostic Tools.

Machine learning approaches infer vitamin D signaling: Critical impact of vitamin D receptor binding within topologically associated domains.

The vitamin D-modulated transcriptome of highly responsive human cells, such as THP-1 monocytes, com...

The Effects of Hydration Status on Cognitive Performances among Young Adults in Hebei, China: A Randomized Controlled Trial (RCT).

: Dehydration may affect cognitive performances as water accounts for 75% of brain mass. The purpose...

Convolutional neural network scoring and minimization in the D3R 2017 community challenge.

We assess the ability of our convolutional neural network (CNN)-based scoring functions to perform s...

Classification of Whole Mammogram and Tomosynthesis Images Using Deep Convolutional Neural Networks.

Mammography is the most popular technology used for the early detection of breast cancer. Manual cla...

Ontology-based literature mining and class effect analysis of adverse drug reactions associated with neuropathy-inducing drugs.

BACKGROUND: Adverse drug reactions (ADRs), also called as drug adverse events (AEs), are reported in...

A supervised learning approach for diffusion MRI quality control with minimal training data.

Quality control (QC) is a fundamental component of any study. Diffusion MRI has unique challenges th...

Evaluation of Natural Language Processing (NLP) systems to annotate drug product labeling with MedDRA terminology.

INTRODUCTION: The FDA Adverse Event Reporting System (FAERS) is a primary data source for identifyin...

Effect of dilution in asymmetric recurrent neural networks.

We study with numerical simulation the possible limit behaviors of synchronous discrete-time determi...

Drug repositioning for prostate cancer: using a data-driven approach to gain new insights.

UNLABELLED: Prostate cancer (PC) is the most common cancer and the third leading cause of cancer dea...

ANTENNA, a Multi-Rank, Multi-Layered Recommender System for Inferring Reliable Drug-Gene-Disease Associations: Repurposing Diazoxide as a Targeted Anti-Cancer Therapy.

Existing drug discovery processes follow a reductionist model of "one-drug-one-gene-one-disease," wh...

Structure-function properties of hypolipidemic peptides.

This review addresses the structure-function properties of hypolipidemic peptides. The cholesterol-l...

Motor and psychosocial impact of robot-assisted gait training in a real-world rehabilitation setting: A pilot study.

In the last decade robotic devices have been applied in rehabilitation to overcome walking disabilit...

Robotic surgery: new robots and finally some real competition!

PURPOSE: For the last 20 years, the predominant robot used in laparoscopic surgery has been Da Vinci...

Computer-aided assessment of breast density: comparison of supervised deep learning and feature-based statistical learning.

Breast density is one of the most significant factors that is associated with cancer risk. In this s...

Tiresias: Context-sensitive Approach to Decipher the Presence and Strength of MicroRNA Regulatory Interactions.

MicroRNAs (miRNAs) are short non-coding RNAs that regulate expression of target messenger RNAs (mRNA...

Ultra-sensitive LC-MS/MS method for the quantification of gemcitabine and its metabolite 2',2'-difluorodeoxyuridine in human plasma for a microdose clinical trial.

In microdose clinical trials a maximum of 100 μg of drug substance is administered to participants, ...

Present therapeutic role of cholesteryl ester transfer protein inhibitors.

Therapeutic interventions aimed at increasing high-density lipoprotein (HDL) levels in order to redu...

LC-MS/MS method for simultaneous determination of diethylcarbamazine, albendazole and albendazole metabolites in human plasma: Application to a clinical pharmacokinetic study.

Combination therapy with anti-filarial drugs is now widely used for treatment of lymphatic filariasi...

Autoinducer-2 Quorum Sensing Contributes to Regulation of Microcin PDI in .

The quorum sensing (QS) signal molecule, autoinducer-2 (AI-2), reaches its maximum concentration du...

Stability of infliximab solutions in different temperature and dilution conditions.

Infliximab is a monoclonal antibody widely used for the treatment of inflammatory diseases. Over the...