Flu & URI

Identification of Immune Signatures of Novel Adjuvant Formulations Using Machine Learning.

Adjuvants have long been critical components of vaccines, but the exact mechanisms of their action and precisely how they alter or enhance vaccine-induced immune responses are often unclear. In this study, we used broad immunoprofiling of antibody, cellular, and cytokine responses, combined with data integration and machine learning to gain insight into the impact of different adjuvant formulation...

Combination Therapy of Clinically Approved Antifungal Drugs Is Enhanced by Conjugation with Silver Nanoparticles.

Silver nanoparticles (SN) have been recently developed as a new class of antimicrobial agents against numerous pathogenic microorganisms. SN have also been used as efficient drug delivery systems and have been linked with increasing drug potency. Here, we demonstrated the enhanced antifungal efficacy of nystatin (NYT) and fluconazole (FLU) after conjugation with SN. The antifungal bioactivity of N...

An open-source k-mer based machine learning tool for fast and accurate subtyping of HIV-1 genomes.

For many disease-causing virus species, global diversity is clustered into a taxonomy of subtypes with clinical significance. In particular, the class...

Estimation of the Basic Reproduction Number and Vaccination Coverage of Influenza in the United States (2017-18).

BACKGROUND: Determining the epidemic threshold parameter helps health providers calculate the coverage while guiding them in planning the process of v...

Representing vaccine misinformation using ontologies.

BACKGROUND: In this paper, we discuss the design and development of a formal ontology to describe misinformation about vaccines. Vaccine misinformatio...

Robotic selection for the rapid development of stable CHO cell lines for HIV vaccine production.

The production of envelope glycoproteins (Envs) for use as HIV vaccines is challenging. The yield of Envs expressed in stable Chinese Hamster Ovary (C...

PIP-EL: A New Ensemble Learning Method for Improved Proinflammatory Peptide Predictions.

Proinflammatory cytokines have the capacity to increase inflammatory reaction and play a central role in first line of defence against invading pathog...

Using preference learning for detecting inconsistencies in clinical practice guidelines: Methods and application to antibiotherapy.

Clinical practice guidelines provide evidence-based recommendations. However, many problems are reported, such as contradictions and inconsistencies. ...

Catechin rich butanol fraction extracted from Acacia catechu L. (a thirst quencher) exhibits immunostimulatory potential.

Acacia catechu L., (Fabaceae) named as "catechu" is a plant, the decoction of heartwood of which is daily consumed as thirst quencher by a good percen...

Novel computer algorithm for cough monitoring based on octonions.

The objective assessment of cough frequency is essential for evaluation of cough and antitussive therapies. Nonetheless, available algorithms for auto...

Prediction of influenza-like illness based on the improved artificial tree algorithm and artificial neural network.

Because influenza is a contagious respiratory illness that seriously threatens public health, accurate real-time prediction of influenza outbreaks may...

A novel triterpenoid 16-hydroxy betulinic acid isolated from attributes multi-faced pharmacological activities.

The aerial parts of extensively used ethnomedicinal plant (Burm. f.) Robinson growing wild in Bangladesh were investigated to isolate and characteriz...

Computational Strategies for Dissecting the High-Dimensional Complexity of Adaptive Immune Repertoires.

The adaptive immune system recognizes antigens an immense array of antigen-binding antibodies and T-cell receptors, the immune repertoire. The interr...

A review of influenza detection and prediction through social networking sites.

Early prediction of seasonal epidemics such as influenza may reduce their impact in daily lives. Nowadays, the web can be used for surveillance of dis...

Meta-Analysis of Expression Datasets: Comparing Virus Infection and Blood-Fed Transcriptomes to Identify Markers of Virus Presence.

The mosquito (L.) is vector of several arboviruses including dengue, yellow fever, chikungunya, and more recently zika. Previous transcriptomic studi...

Haemophilus influenzae type b (Hib) seroprevalence and current epidemiology in England and Wales.

INTRODUCTION: The implementation of the Hib conjugate vaccine in the United Kingdom in 1992 resulted in a rapid decline in invasive Hib disease across...

Anti-pandemic influenza A (H1N1) virus potential of catechin and gallic acid.

BACKGROUND: The pandemic influenza A (H1N1) virus has spread worldwide and infected a large proportion of the human population. Discovery of new and e...

Randomized clinical trial of a single versus a double dose of 13-valent pneumococcal conjugate vaccine in adults 55 through 74 years of age previously vaccinated with 23-valent pneumococcal polysaccharide vaccine.

INTRODUCTION: In older adults, prior administration of 23-valent pneumococcal polysaccharide vaccine (PPSV23) blunts the opsonophagocytic antibody (OP...

Avian influenza overview September - November 2017.

Between 1 September and 15 November 2017, 48 A(H5N8) highly pathogenic avian influenza (HPAI) outbreaks in poultry holdings and 9 H5 HPAI wild bird ev...

Cytotoxicity of the Defensive Secretion from the Medicinal Insect Blaps rynchopetera.

Fairmaire has long been used as a folk medicine by the Yi and Bai ethnic groups in China to treat fever, cough, gastritis, boils, and tumors. In the ...