Gastroenterology

Colorectal cancer surveillance in Lynch syndrome: quality standards, emerging technology and complementary strategies.

Lynch syndrome is the most common hereditary colorectal cancer syndrome, and colonoscopy remains the...

The Crosstalk Role of Intestinal Barrier Damage in the Gut-Organ Axis and its Potential Therapeutic Implications.

Intestinal barrier damage is a pivotal mediator of gut-organ crosstalk and a key contributor to syst...

Development of a Novel Real-Time Computer-Assisted Colonoscopy Diagnostic Tool for Colorectal Neoplasia and Cancer to Enable Personalized Patient Management: Protocol for a Multicenter Proof-of-Concept Study.

BACKGROUND: Accurate real-time classification of colorectal polyps during colonoscopy is essential f...

A white-light endoscopy-based mixed-effects nomogram for predicting small colorectal polyp neoplasia in resource-limited settings.

INTRODUCTION: Accurate optical characterization of small colorectal polyps relies on narrow-band ima...

Engineered MspA Nanopores for Real-Time Detection of Insulin, Its Pharmaceutical Analogues, and Degradation Products.

Nanopore sensors have demonstrated single-molecule resolution for nucleic acids and small molecules,...

Multi-parametric MRI radiomics to predict sensitivity to neoadjuvant chemoradiotherapy based on multi-regions of interest in locally advanced rectal cancer: a multicenter study.

BACKGROUND: To evaluate whether baseline multi-parametric MRI radiomics models, integrating multiple...

Machine learning-based CT radiomics for identifying high risk esophageal varices of bleeding in hepatocellular carcinoma.

PURPOSE: Esophageal variceal (EV) bleeding is a lethal complication in patients with hepatocellular ...

Data-Driven Comorbidity Phenotypes and In-Hospital Outcomes Among Patients With Nonvariceal Upper Gastrointestinal Bleeding: Formative Retrospective Cohort Study.

BACKGROUND: Existing risk scores for nonvariceal upper gastrointestinal bleeding (NVUGIB) may not ad...

In-Hospital Mortality After Aortic Valve Replacement Surgical Versus Transcatheter: A Nationwide Study with Machine Learning-Based Risk Prediction.

INTRODUCTION: Transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (S...

The new landscape of liver transplantation: Evolving candidates, new technologies, and personalized care.

Liver transplantation (LT) is entering a new era shaped by changes in disease epidemiology, candidat...

Design of Screening Cardiometabolic Opportunities Using Transformative Echocardiography Artificial Intelligence (SCOUT-Echo-AI).

BACKGROUND: Steatotic liver disease (SLD) is highly prevalent among individuals with cardiovascular ...

Molecular Detection Technologies for Helicobacter pylori Antibiotic Resistance: Current Status and Clinical Implications.

Helicobacter pylori (H. pylori) infects approximately half of the global population and is closely l...

Automated MRI Series Classification Across Heterogeneous Datasets Using Limited Manual Annotation.

The purpose of this study is to determine the smallest tested fraction of manually labeled training ...

Digital image analysis-based quantification of p53 immunohistochemistry in gastric cancer: a systematic comparison of three-tier cutoff-derivation strategies in tissue microarrays.

BACKGROUND: p53 immunohistochemistry (IHC) is a common surrogate for TP53 alteration, but in gastric...

Emerging Lipid Nanoparticle Targeting Strategies for Extrahepatic Delivery of RNA Therapeutics.

Lipid nanoparticles (LNPs) have transformed RNA therapeutics through their high delivery efficiency,...

Rethinking selection criteria for liver transplantation in hepatocellular carcinoma: from morphology to artificial intelligence.

INTRODUCTION: Liver transplantation (LT) is a uniquely curative treatment for hepatocellular carcino...

UC-DiffuMambaNet: dual-scale state propagation and window attention for ordinal Mayo endoscopic grading.

Automated four-grade Mayo Endoscopic Score (MES) classification is challenging because inflammatory ...

Comment on "Use of Artificial Intelligence for Duodenal Biopsy for Celiac Disease: Developing a Prediction Model for Histopathology Diagnosis".

EsoEinstein: A Multimodal AI System Integrating EGD and FLIP for Esophageal Motility Assessment.

BACKGROUND & AIMS: Achalasia diagnosis relies on integrating endoscopic, functional, and physiologic...

Radiation-Induced Esophagitis: From Clinical Observation to Precision Management.

For the past seven decades, radiation-induced esophagitis (RE) has been a major dose-limiting acute ...

Improving Postpolypectomy Surveillance Decisions Using an Automated Analysis of Colonoscopy and Histopathology Reports: 2-Center Validation Study.

BACKGROUND: Postpolypectomy surveillance intervals derived from colonoscopy findings and histopathol...