Gastroenterology

Early detection of gastric cancer: a novel circulating microbiome DNA based liquid biopsy assay.

Microorganisms play significant roles in gastric cancer (GC) progression. However, it is unknown whether circulating microbiome DNA (cmDNA) possesses GC specific features and could serve as diagnostic biomarker for GC detection. In this study, one cohort of 586 participants from Zhejiang Cancer Hospital were divided randomly into the training and testing datasets. Another cohort of 299 participant...

A multimodal interpretable deep learning-radiomics framework for predicting lymph node metastasis following neoadjuvant chemoradiotherapy in locally advanced rectal cancer: a multicenter validation study.

Accurate assessment of lymph node metastasis (LNM) following neoadjuvant chemoradiotherapy (nCRT) presents a significant clinical challenge and is essential for the management of locally advanced rectal cancer (LARC). In this multicenter study, we developed and externally tested a multimodal MRI-based framework that integrates clinical demographics, handcrafted radiomic signatures, and deep learni...

Network toxicology and bioinformatics reveal potential molecular links between cadmium exposure and pancreatic cancer.

BACKGROUND: Environmental cadmium (Cd) pollution poses a severe threat to human health due to its strong bioaccumulation and high carcinogenicity. Alt...

Decoding the role of H19 in cholestatic liver injury using snRNA-seq, spatial transcriptomics, and machine learning-based disease prediction.

BACKGROUND: Despite recent advances, Primary Sclerosing Cholangitis (PSC)-a chronic obstructive biliary disease-still lacks effective therapies to pre...

Lactylation-related prognostic signature characterized in pancreatic ductal adenocarcinoma through public scRNA-seq dataset and machine learning algorithms: the TOP2A-H3K18la-NQO1 axis orchestrates malignant progression.

BACKGROUND: Lactate promotes histone lactylation, which affects protein transcription and translation, thereby influencing tumour cell progression. Ho...

KRASG12V/A146T mutations are associated with nCRT resistance via enhanced DNA double-strand break repair and support a deep learning prediction framework in LARC.

BACKGROUND: Neoadjuvant chemoradiotherapy (nCRT) is the standard treatment for locally advanced rectal cancer (LARC), yet clinically validated biomark...

Deriving Clavien-Dindo Classification from Administrative Data: Development and External Validation in Hepatobiliary Surgery.

INTRODUCTION: Routine electronic health records (HER)/administrative data could enable time- and cost-efficient, real-time surveillance and health-eco...

Review of systemic therapy in HCC with an approach to response assessment in clinical practice.

Systemic therapy for hepatocellular carcinoma (HCC) has undergone rapid transformation over the past decade, significantly expanding treatment options...

Machine learning-based prediction of hepatocellular carcinoma risk in steatotic liver disease: A nationwide cohort study.

BACKGROUND AND AIMS: Steatotic liver disease (SLD) has emerged as an important risk factor for hepatocellular carcinoma (HCC), often in the absence of...

A machine learning-based interpretable model for predicting pancreatic cancer in chronic pancreatitis patients with focal pancreatic lesions.

BACKGROUND: Pancreatic cancer (PC) is deadly and distinguishing it from inflammatory conditions in chronic pancreatitis (CP) patients is challenging. ...

Prediction of cancer-associated thrombosis by machine learning: results from the Vienna Cancer and Thrombosis Study.

BACKGROUND: Improved risk prediction of cancer-associated venous thromboembolism (VTE) remains an unmet clinical need. We aimed to apply machine learn...

[Stratified application of CA19-9 in the surveillance of postoperative recurrence of pancreatic cancer].

Pancreatic cancer is characterized by high postoperative metastasis and recurrence rates, making the identification of early recurrence markers with h...

[Application research and evolutionary history of risk prediction models for postoperative pancreatic fistula after pancreaticoduodenectomy].

Postoperative pancreatic fistula (POPF) is a severe complication following pancreaticoduodenectomy,among which clinically relevant postoperative pancr...

A Multi-center Gadolinium-ethoxybenzyl-diethylenetriamine Pentaacetic Acid (Gd-EOB-DTPA) MRI Dataset with Expert Annotations and clinicopathological data.

Liver resection is a cornerstone treatment for liver tumors, yet post-hepatectomy liver failure (PHLF) remains a severe and life-threatening complicat...

Reassessing negative 24 h pH impedance tests for hidden gastroesophageal reflux disease using multi feature anomaly detection.

Gastroesophageal reflux disease (GERD) diagnosis traditionally relies on acid exposure time (AET) obtained from 24-h multichannel intraluminal impedan...

Deep chemical structure graph learning deciphers the lipotoxicity code of hypertriglyceridemic pancreatitis.

The discrepancy between serum triglyceride levels and the clinical severity of hyperlipidemic acute pancreatitis (HLAP) complicates risk stratificatio...

What Are Computer-Assisted Methods Achieving in Fine-Needle Aspiration Cytology of the Pancreas? A Systematic Review and Meta-Analysis.

OBJECTIVE: Pancreatic malignancies present major diagnostic challenges. The gold standard for diagnosis is endoscopic ultrasound-guided fine-needle as...

Evolution of Gastrointestinal Inflammatory Diseases and Neoplasm Burden in Super-Elderly Populations: Integrated GBD 2023, CHARLS, and CLHLS Analyses of China and G20 Countries.

BACKGROUND: Rapid population aging has profoundly altered the epidemiological profile of gastrointestinal diseases in individuals aged ≥75 years. Alth...

Diagnostic value of integrated albumin-to-leukocyte ratio risk modeling stratification and machine learning approaches for prediction of spontaneous bacterial peritonitis in cirrhotic patients.

BACKGROUND: Spontaneous bacterial peritonitis (SBP) remains a life-threatening complication of liver cirrhosis, requiring accurate and rapid predictio...

Integrating single-cell analysis and digital pathology for risk stratification in pancreatic cancer.

Early liver metastasis is a major factor contributing to the poor prognosis of pancreatic ductal adenocarcinoma (PDAC). Single-cell RNA sequencing (sc...