Genetics

Genomic and Transcriptomic Profiling of High-risk Bladder Cancer Reveals Diverse Molecular and Microenvironment Ecosystems.

BACKGROUND AND OBJECTIVE: High-risk bladder cancer recurs in 30% of cases and causes fatal outcomes in 10% within 2 yr despite surgical resection, endoscopic surveillance, and bacillus Calmette-Guérin (BCG) immunotherapy. The global shortage of BCG highlights the urgent need for alternative or complementary strategies. This study aimed to identify molecular subtypes and develop a precision framewo...

Precision Nutritional Genomics, Gut Microbiota and Artificial Intelligence in Chronic Kidney Disease.

Chronic kidney disease (CKD) is a prevalent global health issue, and nutritional management of CKD is an integral component through all stages of the disease. However, response to dietary interventions varies, potentially due to genetic variations influencing metabolic pathways. This review highlights key gene-diet interactions relevant to CKD management, including risk factors and comorbidities s...

Automated detection and characterization of small cell lung cancer liver metastasis on computed tomography.

PURPOSE: Small cell lung cancer (SCLC) is an aggressive disease with diverse phenotypes that reflect the heterogeneous expression of tumor-related gen...

Autonomous spiking neural P systems with coupled neurons.

Abstracted from the way spiking neurons transmit and process information, spiking neural P systems (SNP systems) are becoming increasingly popular as ...

Applying an interpretation model for body fluid mixture identification.

Confirmatory body fluid identification via the detection of specific messenger RNA (mRNA) species is important in circumstances where a conventional t...

Brain metabolic imaging with 18 F-PET-CT and machine-learning clustering analysis reveal divergent metabolic phenotypes in patients with amyotrophic lateral sclerosis.

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by significant clinicopathologic heterogeneity. Th...

Public Preferences for Emerging Cancer Screening Modalities: A Systematic Review of Discrete Choice Experiments.

BACKGROUND: Early detection of cancer reduces mortality and morbidity, but conventional screening methods often face challenges such as invasiveness, ...

A Datasheet for Age-Related Eye Disease Study 2 on the Database of Genotypes and Phenotypes.

OBJECTIVE: To provide a comprehensive summary of the controlled-access Age-Related Eye Disease Study 2 (AREDS2) data elements, encompassing phenotypic...

Probiotics, psychobiotics, and postbiotics: a therapeutic modality for the management of schizophrenia.

Schizophrenia is a debilitating, chronic neuropsychiatric disorder, a multifactorial disorder combining genetic, neurodevelopmental, immunological, an...

Prediction of protein thermostability trends based on the self-attention mechanism driven sparse convolutional network.

Artificial intelligence (AI)-assisted thermostability prediction of proteins can significantly alleviate the burden of mutation screening, thereby enh...

Honey bee nutritranscriptomics reveals key insights towards precision nutrition.

INTRODUCTION: Honey bees are essential managed pollinators faced by nutritional deficiencies which contributes to worldwide colony losses. The integra...

EnsembleRegNet: Interpretable deep learning for transcriptional network inference from single-cell RNA-seq.

Gene regulatory networks (GRNs) govern gene expression and cellular identity, but accurately inferring their structure from high-dimensional single-ce...

Machine learning approaches to predict drug resistance in tuberculosis.

Tuberculosis (TB) remains a global health crisis, with 10.8 million cases and 1.25 million deaths in 2023. The rise of drug-resistant TB has complicat...

Structure and function of voltage-gated sodium channel Nav1.6: Involvement in the pathological process of neural injury.

The voltage-gated sodium channel Nav1.6, encoded by the sodium voltage-gated channel alpha subunit 8 gene, is a crucial regulator of neuronal excitabi...

Multiomics combined with machine learning defines unique molecular subtypes of cholangiocarcinoma and identifies TNK1 as a therapeutic target.

BACKGROUND AND AIMS: Cholangiocarcinoma (CCA) is one of the most lethal cancers, characterized by molecular heterogeneity and treatment resistance. To...

Evolutionary Channel Pruning for Style-Based Generative Adversarial Networks.

Generative Adversarial Networks (GANs) have demonstrated remarkable success in high-quality image synthesis, with StyleGAN and its successor, StyleGAN...

Liquid biopsy based on multi-targeted capture of urinary tumor DNA combined with machine learning to detect urothelial carcinoma: a multicenter prospective study.

PURPOSE: Diagnostics for urothelial carcinoma have low sensitivity, thereby negatively impacting diagnostic outcomes. Herein, we present BiovueUro, a ...

Tissue-Engineered Endothelial Keratoplasty with Controlled Cell Density: Toward Super TEEKs.

Over the past 20 years, endothelial keratoplasty procedures have revolutionized the treatment of corneal endothelial disorders. These conditions have ...

Genome-wide association study bridging genomics-phenomics gap in natural plant populations.

The planet hosts half a million plant species exhibiting a spectacular diversity of plant forms with genomes driving phenotypic variations. The genome...

Nivolumab plus ipilimumab for potentially resectable hepatocellular carcinoma: Long-term efficacy and biomarker exploration.

BACKGROUND & AIMS: Immune checkpoint inhibitor-based combination therapy has demonstrated high objective response rates in patients with hepatocellula...