Genetics

Fetal nucleated red blood cell analysis for non-invasive prenatal diagnostics using a nanostructure microchip.

Cell-free DNA has been widely used in non-invasive prenatal diagnostics (NIPD) nowadays. Compared to these incomplete and multi-source DNA fragments, fetal nucleated red blood cells (fNRBCs), once as an aided biomarker to monitor potential fetal pathological conditions, have re-attracted research interest in NIPD because of their definite fetal source and the total genetic information contained in...

Resistance gene identification from Larimichthys crocea with machine learning techniques.

The research on resistance genes (R-gene) plays a vital role in bioinformatics as it has the capability of coping with adverse changes in the external environment, which can form the corresponding resistance protein by transcription and translation. It is meaningful to identify and predict R-gene of Larimichthys crocea (L.Crocea). It is friendly for breeding and the marine environment as well. Lar...

Toxoplasma gondii transmission by artificial insemination in sheep with experimentally contaminated frozen semen.

Toxoplasma gondii is a parasite considered one of the major causes of reproductive problems in sheep. Furthermore, the presence of the agent in ram se...

High-Throughput Robotically Assisted Isolation of Temperature-sensitive Lethal Mutants in Chlamydomonas reinhardtii.

Systematic identification and characterization of genetic perturbations have proven useful to decipher gene function and cellular pathways. However, t...

A Review on Methods for Detecting SNP Interactions in High-Dimensional Genomic Data.

In this era of genome-wide association studies (GWAS), the quest for understanding the genetic architecture of complex diseases is rapidly increasing ...

Clinical, molecular, and genetic evaluation of galactosemia in Turkish children.

AIM: Galactosemia is a carbohydrate metabolism disorder with autosomal recessive inheritance. The most frequent enzyme deficiency is galactose-1-phosp...

Efficacy according to blind independent central review: Post-hoc analyses from the phase III, randomized, multicenter, IPASS study of first-line gefitinib versus carboplatin/paclitaxel in Asian patients with EGFR mutation-positive advanced NSCLC.

OBJECTIVE: The Phase III, randomized, open-label IPASS study (NCT00322452) of first-line epidermal growth factor receptor tyrosine kinase inhibitor (E...

Lung Cancer Classification Employing Proposed Real Coded Genetic Algorithm Based Radial Basis Function Neural Network Classifier.

A proposed real coded genetic algorithm based radial basis function neural network classifier is employed to perform effective classification of healt...

Machine-learning approach identifies a pattern of gene expression in peripheral blood that can accurately detect ischaemic stroke.

Early and accurate diagnosis of stroke improves the probability of positive outcome. The objective of this study was to identify a pattern of gene exp...

Introducing a Stable Bootstrap Validation Framework for Reliable Genomic Signature Extraction.

The application of machine learning methods for the identification of candidate genes responsible for phenotypes of interest, such as cancer, is a maj...

A Graph Approach to Mining Biological Patterns in the Binding Interfaces.

Protein-RNA interactions play important roles in the biological systems. Searching for regular patterns in the Protein-RNA binding interfaces is impor...

PACE: Probabilistic Assessment for Contributor Estimation- A machine learning-based assessment of the number of contributors in DNA mixtures.

The deconvolution of DNA mixtures remains one of the most critical challenges in the field of forensic DNA analysis. In addition, of all the data feat...

Random Subspace Aggregation for Cancer Prediction with Gene Expression Profiles.

. Precisely predicting cancer is crucial for cancer treatment. Gene expression profiles make it possible to analyze patterns between genes and cancers...

CS3, a New GABA-Producing Strain Isolated from Thai Fermented Shrimp (-).

- is a popular traditional Thai fermented shrimp product. It is rich in glutamic acid, which is the major substrate for the biosynthesis of gamma-amin...

Inhibition of EGF expression and NF-κB activity by treatment with quercetin leads to suppression of angiogenesis in nasopharyngeal carcinoma.

The present study was performed to investigate the effect of quercetin on nasopharyngeal carcinoma (NPC) angiogenesis. The real-time RT-PCR and enzyme...

A case of rapid amelioration of hepatitis C virus-associated cryoglobulinemic membranoproliferative glomerulonephritis treated by interferon-free directly acting antivirals for HCV in the absence of immunosuppressant.

Mixed cryoglobulinemic syndrome, which is a systemic vasculitis characterized by the immune complex deposition in small- and medium-sized arteries and...

Prediction of microRNAs involved in immune system diseases through network based features.

MicroRNAs are a class of small non-coding regulatory RNA molecules that modulate the expression of several genes at post-transcriptional level and pla...

Mapping membrane activity in undiscovered peptide sequence space using machine learning.

There are some ∼1,100 known antimicrobial peptides (AMPs), which permeabilize microbial membranes but have diverse sequences. Here, we develop a suppo...

SNooPer: a machine learning-based method for somatic variant identification from low-pass next-generation sequencing.

BACKGROUND: Next-generation sequencing (NGS) allows unbiased, in-depth interrogation of cancer genomes. Many somatic variant callers have been develop...

Transcriptome assists prognosis of disease severity in respiratory syncytial virus infected infants.

Respiratory syncytial virus (RSV) causes infections that range from common cold to severe lower respiratory tract infection requiring high-level medic...