GERD

Comparative outcomes of balloon-expandable versus self-expanding transcatheter aortic valves: insights from a large-scale German registry.

BACKGROUND: While transcatheter aortic valve replacement (TAVR) has become an established alternative to surgical aortic valve replacement (SAVR), the comparative outcomes of balloon-expandable (BE) and self-expanding (SE) valve technologies remain an area of ongoing investigation. METHODS: Using the German DESTATIS database, we analyzed 48,565 transfemoral TAVR procedures performed between 2021 a...

AI-ECG Detection of Structural Heart Disease in the Community Setting: Transportability and Spectrum Effects in the PREVUE-VALVE Study.

BACKGROUND: Artificial intelligence (AI) diagnostic models are typically developed in hospital-based populations enriched for disease prevalence and severity, where distinctions between health and disease are pronounced. When deployed in community-dwelling populations with lower prevalence and milder phenotypes, these distinctions may become less well-defined, raising questions about transportabil...

Evaluating sex bias in artificial intelligence-based echocardiographic analysis: a retrospective study on individuals with normal cardiac function and patients with systolic and diastolic dysfunction.

BACKGROUND: Artificial intelligence (AI) has the potential to improve echocardiography. However, AI systems may exhibit sex bias, reproducing societal...

Transformer-Based Deep Learning Framework for Automated Lesion Detection in Capsule Endoscopy: A Comparative Study With CNN Architectures.

GOALS: To compare a vision transformer with 2 convolutional neural network architectures for multiclass lesion classification in capsule endoscopy ima...

VIGIL: Vision-Language Guided Multiple Instance Learning Framework for Ulcerative Colitis Histological Healing Prediction.

OBJECTIVE: Ulcerative colitis (UC) is characterized by chronic inflammation with alternating remission-relapse cycles, necessitating precise histologi...

Integrative machine learning and single-nucleus transcriptomics reveal MAPK-centered neuronal responses underlying the potential Alzheimer's disease risk of GenX.

Hexafluoropropylene oxide-dimer acid (GenX or HFPO-DA) is a novel per- and polyfluoroalkyl substance developed as a replacement for legacy compounds, ...

MINPP1, HES4 and SLCO5A1 as core signature genes mediating the effects of type 2 diabetes on coronary artery bypass grafting.

PURPOSE: This study aimed to identify the signature genes that mediate the effects of type 2 diabetes (T2D) on coronary artery bypass grafting (CABG),...

Stephania cepharantha Hayata (Baiyaozi) attenuates cirrhosis-associated intestinal barrier injury by restoring mitochondrial function and suppressing PI3K/AKT signaling.

ETHNOPHARMACOLOGICAL RELEVANCE: Baiyaozi, the dried tuberous root of Stephania cepharantha Hayata, has long been used in traditional Chinese medicine ...

Machine Learning-Assisted Prediction of Varicocele Grade Using Multidimensional Spermatic Vein Reflux Time Analysis.

BACKGROUND: Varicocele (VC) grading has long relied on qualitative assessments of venous diameter and reflux signals, lacking standardization. OBJECTI...

Multimodal graph-based classification of esophageal motility disorders.

PURPOSE: Diagnosing esophageal motility disorders, including dysphagia, pose significant challenges due to the complexity of high-resolution impedance...

Protein-protein interaction-mediated signaling networks in ischemic stroke: from molecular mechanisms to therapeutic strategies.

The pathological progression of ischemic stroke is driven by a dynamic signaling network mediated by protein-protein interactions (PPI) that involves ...

Ascending aorta and pure aortic regurgitation transcatheter aortic valve replacement: insights from the National Transcatheter Valve Therapeutics Registry.

BACKGROUND: Data regarding the association between self-expandable transfemoral transcatheter aortic valve replacement (TF-TAVR) and pure native aorti...

Unveiling the power of TIIC: A prognostic tool for esophageal adenocarcinoma.

BACKGROUND: Esophageal adenocarcinoma (EAC) remains a lethal malignancy with limited prognostic tools for guiding immunotherapy. Tumor-infiltrating im...

The Clinical Course of Chronic Venous Disease.

OBJECTIVE: The clinical manifestations of chronic venous disease (CVD) range from varicose veins (VV) to, ultimately, venous ulceration, representing ...

Artificial Intelligence based identification of druggability of essential hypothetical proteins in Plasmodium falciparum.

Malaria, caused by Plasmodium falciparum is a deadly disease and remains a global health concern. With the emergence of resistance to artemisinin; it ...

Machine learning-based screening tool for predicting the risk of oropharyngeal dysphagia in patients with ischemic stroke.

PURPOSE: Dysphagia frequently complicates recovery after stroke, necessitating effective predictive tools. This study aimed to develop supervised mach...

Beyond the flow: the evolving role of magnetic resonance imaging in arteriovenous shunt evaluation.

Although digital subtraction angiography remains the gold standard for the diagnosis and treatment planning of intracranial arteriovenous shunts (AVS)...

Predictive Value of Endoscopy in the Identification of Complete Response After Neoadjuvant Therapy for Rectal Adenocarcinoma.

BACKGROUND: Large-scale evidence on the role of endoscopy alone as the assessment tool to identify complete response after neoadjuvant therapy in loca...

Integrative Multi-Omics Analysis Identifies Key Molecular Targets Linking Bisphenol A Exposure to Gestational Diabetes Mellitus.

Bisphenol A (BPA) exposure is associated with gestational diabetes mellitus (GDM); however, the underlying molecular mechanisms remain elusive. This s...

Clinical and Echocardiographic Factors Associated With AI-Estimated Atrial Fibrillation Likelihood During Sinus Rhythm in Patients With Documented Paroxysmal Atrial Fibrillation.

BACKGROUND: Artificial intelligence-enabled electrocardiography (AI-ECG) has emerged as a promising tool for identifying patients with atrial fibrilla...