Hepatitis

Emerging and Re-Emerging Viral Infections in Poultry: Integrating Traditional and AI-Based Control Strategies.

Poultry production remains significantly challenged by emerging and re-emerging avian viral diseases, which are influenced by host-pathogen interactions, viral evolution, and intensified farming systems. Viruses like avian influenza viruses (AIV) and Newcastle disease virus (NDV) remain the most persistent threats, while chicken anaemia virus (CAV), avian metapneumovirus (aMPV), adenoviruses, and ...

Risk-aware artificial intelligence for translational vaccine design.

Artificial intelligence has accelerated epitope and antigen discovery, but prediction alone cannot determine vaccine readiness. Translational design requires risk-aware prioritization that connects immunogenicity with protection, population human leukocyte antigen (HLA) coverage, safety, immune correlates, model uncertainty, interpretability, and experimental feasibility. This review proposes a fr...

Disarming cGAS-STING hyperactivation in autoimmune and inflammatory diseases: Pathogenic mechanisms and emerging therapeutic strategies.

Aberrant activation of the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway has been increasingly recognized as a key dri...

Artificial Intelligence Can Direct Patients Toward a Complaint-specific Musculoskeletal Provider.

INTRODUCTION: Patients with musculoskeletal complaints often search online to identify an appropriate healthcare provider. With the increasing availab...

Somalia's lifeline: Digitalization and AI.

Somalia's fragile health system, strained by decades of conflict, climate shocks, and persistently low immunization coverage, remains dangerously vuln...

Bridging fibrosis and function: an integrated mechanistic and therapeutic framework for Peyronie's disease and related erectile dysfunction.

INTRODUCTION: Peyronie's disease (PD) and erectile dysfunction (ED) are prevalent and frequently coexisting male sexual disorders that share endotheli...

CCT2 Promotes Immune Escape in Colorectal Cancer by Regulating the JAK1-STAT3-PD-L1 Axis.

BACKGROUND: Colorectal cancer (CRC) is a major global health burden. While immune checkpoint inhibitors have greatly advanced cancer therapy, their th...

Surface-Enhanced Raman Spectroscopy for Viral Diagnostics: Principles, Strategies, Clinical Challenges, and Future Directions.

Viral outbreaks such as SARS-CoV, MERS-CoV, and COVID-19 underscore the urgent need for rapid, sensitive, and scalable diagnostic technologies. Curren...

Stephania cepharantha Hayata (Baiyaozi) attenuates cirrhosis-associated intestinal barrier injury by restoring mitochondrial function and suppressing PI3K/AKT signaling.

ETHNOPHARMACOLOGICAL RELEVANCE: Baiyaozi, the dried tuberous root of Stephania cepharantha Hayata, has long been used in traditional Chinese medicine ...

Identification of novel PKR inhibitory chemotypes via integrated molecular modelling and machine learning.

Interferon-inducible RNA-dependent protein kinase (PKR) is an emerging therapeutic target involved in cancer, neurodegeneration, and inflammatory diso...

MAFLD/MASLD: Past, Present, and Future.

Metabolic dysfunction-associated steatotic liver disease (MASLD), also known as nonalcoholic fatty liver disease and metabolic dysfunction-associated ...

Network-guided transcriptomics identifies drug-linked host-response biomarkers in tuberculosis disease-state transition.

Distinguishing active tuberculosis (ATB) from the post-therapy state remains a key challenge in disease monitoring, as host-response signatures are of...

Real-world analysis of depression-related adverse events associated with the adsorbed anthrax vaccine: integrating pharmacovigilance signals, machine learning risk prediction, and transcriptomic mechanisms.

BACKGROUND: Anthrax remains a life-threatening zoonotic disease in resource-limited settings. Adsorbed anthrax vaccine (AVA, BioThrax) is the only Uni...

Sex-specific associations of the bilirubin-to-albumin ratio with lung cancer risk: evidence from Cox regression and causal survival forest analysis.

BACKGROUND: The bilirubin-to-albumin (BA) ratio may reflect the balance between circulating bilirubin and albumin-related binding capacity, but its as...

Zero-shot segmentation and tumor diameter measurement of soft tissue sarcomas on MRI using a multimodal large language model.

OBJECTIVES: To evaluate the zero-shot capabilities of a multimodal deep learning model (Gemini 3.0) in segmenting Soft Tissue Sarcomas (STS) on MRI an...

Optimising Pharmacovigilance Efficiency with MLIT (Machine Learning for Intelligent Triage): A Tool for Statistical Safety Alerts.

BACKGROUND AND AIM: Pharmacovigilance is essential to ensuring patient safety by enabling timely identification of adverse reactions in increasingly c...

Preferences for AI-Enabled Health Care Technologies: Systematic Review of Discrete Choice Experiments and Reporting Quality Assessment Using the DIRECT Checklist.

BACKGROUND: AI is increasingly being integrated into health care, making it important to understand stakeholder preferences for AI-enabled technologie...

Beyond Accuracy: A Mixed-Methods Audit of Chain-of-Thought Failures in LLM-Based COVID-19 Vaccine Stance Detection.

This mixed-methods study assessed whether reasoning-enabled large language models (LLMs) can classify stances towards COVID-19 vaccination on X (forme...

Senkyunolide I Inhibits mtDNA-cGAS-STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis.

Ulcerative colitis (UC) is a chronic inflammatory bowel disease with limited therapeutic options. The cyclic GMP-AMP synthase (cGAS)-stimulator of int...

Modelling the impact of awareness campaigns on HPV transmission dynamics: a neural network-enhanced mathematical model.

HPV is the most common sexually transmitted infection; most sexually active individuals are exposed to HPV at some point in their lives, and the major...