Hepatitis

Artificial intelligence predicts recurrent autoimmune hepatitis after liver transplantation in a multicenter cohort study.

BACKGROUND: Autoimmune hepatitis (AIH) is an important indication for liver transplantation (LT), but recurrence affects over 30% of recipients, threatening long-term survival. Current strategies to prevent recurrence and progressive graft fibrosis remain suboptimal, with limited evidence to guide selection of immunosuppressive regimens. We aimed to develop a dynamic, individualized, artificial in...

A 3-year wastewater-based epidemiology study of noroviruses in Senegal.

UNLABELLED: Norovirus is a leading cause of acute gastroenteritis worldwide due to its high contagiousness, widespread transmission, and the lack of treatment or vaccine. In Senegal, no routine community-level monitoring is performed, and most available data concern other enteric viruses, leaving a gap in understanding norovirus circulation. To assess the potential of wastewater surveillance as an...

Transfer learning prediction of 2-year native liver survival in biliary atresia following Kasai portoenterostomy using early perioperative biochemical data up to 3 months postoperatively.

BACKGROUND: Biliary atresia (BA), a rare but life-threatening neonatal cholestatic disorder, necessitates Kasai portoenterostomy (KPE) as the primary ...

Machine learning prediction of complications after surgery in cirrhotic patients: Integrating nutritional risk with liver function.

Liver disease is among the most common medical conditions in the world, leading to high rates of morbidity and death. Early identification of liver di...

IDEAL-Age: an interpretable deep learning framework for single-cell resolution profiling of immunological aging.

Immunosenescence increases susceptibility to infection and reduces vaccine responsiveness, yet bulk transcriptomic clocks obscure the cellular heterog...

Direct Reconstruction of High-Fidelity Electrocardiogram Signals From Vector-Based PDF Files With Integrated Deep Learning for Multiparameter Estimation: Retrospective Methodological Study.

BACKGROUND: Electrocardiograms (ECGs) are commonly stored in PDF, particularly as vector-based files generated by ECG management systems. Previous stu...

Fibrosis regression in chronic liver disease: the pathologist's view.

Numerous observations have indicated that significant amounts of liver fibrosis can either completely disappear or be substantially remodelled followi...

Artificial Intelligence and Generative Models in Hepatology: From Large Language Models to Digital Pathology in Liver Disease Diagnosis and Treatment.

Artificial intelligence (AI), particularly foundation and generative models, is reshaping the practice of hepatology through enhanced knowledge synthe...

Model-Guided Optimization of a Low-Serum Medium for Madin-Darby Canine Kidney Cells Using a Kolmogorov-Arnold Network and Bayesian Optimization.

Madin-Darby canine kidney (MDCK) cells are important hosts for cell culture-based viral vaccine production, but fetal bovine serum (FBS) supplementati...

Multiomics and artificial intelligence identify infection associated subtypes and prognostic signatures in hepatocellular carcinoma.

UNLABELLED: Hepatocellular carcinoma (HCC) remains a major global health burden with persistently high morbidity and mortality. Dysregulation of the t...

Personalized cancer vaccines: bridging immune-oncology and precision medicine for advanced therapeutics.

Despite advancements in therapeutic cancer vaccines, clinical translation has been hindered by limited efficacy, with Sipuleucel-T remaining the only ...

Chemical-Sensing Catheters for Long-Term and Personalized Therapeutic Management.

Long-term intravenous catheterization is vital for delivering chemotherapy to cancer patients and parenteral nutrition to those with intestinal failur...

Evolution of swine influenza surveillance and one health governance in Taiwan: from zoonotic risk management to integrated preparedness.

Influenza A viruses (IAVs) remain a persistent global threat because of rapid antigenic change, frequent genetic reassortment, and cross-species trans...

Multi-omics and artificial intelligence nominate PCLAF as a prognostic and druggable target for hepatitis B virus-associated hepatocellular carcinoma.

BACKGROUND: PCLAF (PCNA clamp-associated factor) is a protein involved in DNA replication and DNA repair. Aberrant PCLAF expression has been reported ...

VN1K is a pangenome-informed multi-omics and phenomics resource for the Vietnamese population.

The population of Vietnam remains underrepresented in global genomic databases. Here, we present VN1K, a resource of multi-omics and phenotypic inform...

Recent Advances in Immunotherapy for Breast Cancer: An Updated Review.

Immunotherapy has revolutionized the treatment landscape of breast cancer, particularly for triple-negative breast cancer (TNBC), yet primary and acqu...

Evaluating the reliability and information quality of ChatGPT responses on vaccine hesitancy: an expert panel study.

BACKGROUND: Vaccine hesitancy is a major public health problem that threatens global immunisation programmes. The use of artificial intelligence-based...

Attribution of PM2.5-Induced Transcriptomic Perturbation to Toxic Components.

Ambient fine particulate matter (PM2.5) is a chemically complex mixture whose health impacts are not fully captured by particle mass. Here, we develop...

Fibrillarin-mediated 2'-O-methylation serves as a translation brake on uncapped enterovirus RNA.

2'-O-methylation (Nm) is a key epitranscriptomic mark across diverse RNAs, yet its role in antiviral defense remains largely unexplored. To systematic...

Viral protease-initiated lytic cell death as a universal antiviral mRNA therapy.

While gasdermin (GSDM)-mediated pyroptosis is a potent immune effector, its antiviral potential remains largely untapped. Here, we introduce viral pro...