Infectious Disease

Latest AI and machine learning research in infectious disease for healthcare professionals.

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Data-driven supervised learning of a viral protease specificity landscape from deep sequencing and molecular simulations.

Biophysical interactions between proteins and peptides are key determinants of molecular recognition specificity landscapes. However, an understanding of how molecular structure and residue-level energetics at protein-peptide interfaces shape these landscapes remains elusive. We combine information from yeast-based library screening, next-generation sequencing, and structure-based modeling in a su...

Dec 26 2018 30587591

Ceftaroline Fosamil as an Alternative for a Severe Methicillin-resistant Staphylococcus aureus Infection: A Case Report.

Bacteremia secondary to methicillin-resistant Staphylococcus aureus (MRSA) is a dreaded medical condition that is not only associated with a significant medical cost but also carries high morbidity and mortality. The poor clinical outcomes seen in MRSA patients and the nephrotoxic effects of high-doses of vancomycin are challenging its current status as the first-line treatment for MRSA. Fortunate...

Dec 25 2018 30820395
Anthelmintic effect and tissue alterations induced in vitro by hydrolysable tannins on the adult stage of the gastrointestinal nematode Haemonchus contortus.

Haemonchus contortus constitutes a severe problem for ruminant's production, it is the most frequent nematode parasite both in template and tropical r...

Dec 24 2018 30736941
Smartphone-based fluorescent lateral flow immunoassay platform for highly sensitive point-of-care detection of Zika virus nonstructural protein 1.

Simple, inexpensive, and rapid diagnostic tests in low-resource settings with limited laboratory equipment and technical expertise are instrumental in...

Dec 23 2018 30782365
Sensitive electrochemical detection of gp120 based on the combination of NBD-556 and gp120.

As is known, the employment of molecular imprinting polymer (MIP) as specific sensing materials in sensors, namely MIP-based sensors. In this contribu...

Dec 23 2018 30683395
Case study: Evaluating quarter and composite milk sampling for detection of subclinical intramammary infections in dairy cattle.

Our objective was to evaluate a 200,000 cells/mL somatic cell count (SCC) cut-point on both the quarter and composite level to determine its effective...

Dec 23 2018 30670186
PADI-web corpus: Labeled textual data in animal health domain.

Monitoring animal health worldwide, especially the early detection of outbreaks of emerging pathogens, is one of the means of preventing the introduct...

Dec 23 2018 30671512
NommPred: Prediction of Mitochondrial and Mitochondrion-Related Organelle Proteins of Nonmodel Organisms.

To estimate the functions of mitochondria of diverse eukaryotic nonmodel organisms in which the mitochondrial proteomes are not available, it is neces...

Dec 23 2018 30626996
Peptide Extract from Exhibits Broad-Spectrum Antibacterial Activity.

Increasing reports of infectious diseases worldwide have become a global concern in recent times. Depleted antibiotic pipelines, rapid and complex cas...

Dec 23 2018 30671464
Photoluminescence-tunable fluorescent carbon dots-deposited silver nanoparticle for detection and killing of bacteria.

Innovative methods to detect and kill pathogenic bacteria have a pivotal role in the eradication of infectious diseases and the prevention of the grow...

Dec 22 2018 30678948
Rapid and specific detection of Salmonella infections using chemically modified nucleic acid probes.

Salmonella is a leading source of bacterial foodborne illness in humans, causing gastroenteritis outbreaks with bacteraemia occurrences that can lead ...

Dec 21 2018 30712586
HIV is associated with endothelial activation despite ART, in a sub-Saharan African setting.

OBJECTIVE: To study the relationship between endothelial dysfunction, HIV infection, and stroke in Malawians.

Dec 21 2018 30697583
Mutations associated with change of susceptibility to lincosamides and/or macrolides in field and laboratory-derived Mycoplasma californicum strains in Japan, and development of a rapid detection method for these mutations.

Five mutations involved in changing of susceptibility to lincosamides and/or macrolides were investigated in field isolates of Mycoplasma californicum...

Dec 21 2018 30642602
Development of a bacteriophage-based Method for Detection of O157:H7 in Fresh Vegetables.

In this study, a method using a recombinant phage for detection of O157:H7 in fresh vegetables was investigated. Four kinds of fresh vegetables, i.e....

Dec 21 2018 31998575
Extracellular Vesicles Released by () Promote Disease Progression and Induce the Production of Different Cytokines in Macrophages and B-1 Cells.

The extracellular vesicles (EVs) released by can contribute to the establishment of infection and host immunomodulation. In this study, we characteri...

Dec 21 2018 30627118
Dual Biocontrol Potential of the Entomopathogenic Fungus, , for Both Aphids and Plant Fungal Pathogens.

Dual biocontrol of both insects and plant pathogens has been reported for certain fungal entomopathogens, including and spp. In this study, we demon...

Dec 21 2018 30637153
Acute Retroviral Syndrome Presenting as Acute Hepatitis.

Acute retroviral syndrome (ARS) can present as a wide array of clinical manifestations. Establishing a diagnosis early in the disease course can provi...

Dec 20 2018 30820375
Impact of Graphene Exposure on Microbial Activity and Community Ecosystem in Saliva.

Graphene-based nanomaterials (GMs) are served as great promising agents for the prevention and therapy of infectious diseases. However, their dental a...

Dec 19 2018 35016345
Randomized Controlled Pilot Study of Antiretrovirals and a Behavioral Intervention for Persons With Acute HIV Infection: Opportunity for Interrupting Transmission.

BACKGROUND: Persons with acute HIV infection (AHI) have heightened transmission risk. We evaluated potential transmission reduction using behavioral a...

Dec 19 2018 30648131
Elevated α-Fetoprotein in the Absence of Carcinoma Caused by Relapse of Hepatitis C Viral Infection after Liver Transplantation.

We report a rare case of marked elevation of α-fetoprotein in the absence of hepatocellular carcinoma caused by a relapse of hepatitis C virus (HCV) i...

Dec 19 2018 30643846
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