Inflammatory Bowel Disease

Outer Retinal Erosion and Outer Retinal Pinching at the Origin of Subretinal Fluid in Central Serous Chorioretinopathy.

PURPOSE: To characterize early outer retinal changes at the site of origin of subretinal fluid (SRF) in central serous chorioretinopathy (CSCR). To investigate their pathophysiologic and clinical significance. DESIGN: Retrospective, nonconcurrent, multicenter cohort study. SUBJECTS: A total of 87 eyes of 87 patients with primary or recurrent CSCR (episode duration <4 months) and one or more fluore...

NPHS2 Revisited Through 208 Cases and Podocin Complex Modeling.

INTRODUCTION: Steroid-resistant nephrotic syndrome (SRNS) is the leading cause of chronic glomerular disease in individuals under 25 years of age. Biallelic variants in NPHS2, encoding podocin, are the most common monogenic etiology. Podocin homo-oligomerizes to a critical slit diaphragm complex. NPHS2 genotype-phenotype relationships and podocin's assembly architecture remain incompletely defined...

The optimal conditioning intensity of stem cell transplantation for acute myeloid leukemia in complete remission.

UNLABELLED: This study aimed to identify patient groups in which myeloablative conditioning (MAC) or reduced-intensity conditioning (RIC) regimens ind...

Exploring an Intermediate Colorectal Cancer Screening Test Based on Stool Proteomics and Machine Learning for Optimizing the Selection of Patients for Colonoscopy Identified from FIT.

The fecal immunochemical test (FIT) for detecting fecal occult blood, used alone or in combination with other stool biomarkers, has been demonstrated ...

Identifying Transdiagnostic Predictors of Depression Across Psychoses: Informing Stratified Antidepressant Treatments.

INTRODUCTION: Depression frequently co-occurs with psychosis and is associated with poor outcomes. Early identification of patients at risk of persist...

[AI and clinical reasoning : between promises and the risks of "deskilling"].

The rise of AI in healthcare offers major potential for diagnosis and learning but also exposes to a worrying risk of "deskilling." Recent data from c...

Letter Regarding "Artificial Intelligence Model for Automated Identification of Bowel Preparation for Colonoscopy (AI-PREPOO): A Multicenter Study".

Artificial intelligence enhances screening efficiency for inflammatory bowel disease clinical trials: a prospective study.

An LLM-based AI tool significantly improved identification of potentially eligible patients and screening efficiency for IBD clinical trials, outperfo...

Contemporary Management of Radiation Necrosis: Insights and Avenues.

Radiation necrosis (RN) remains a challenging complication of upfront radiation therapy for both brain metastases and primary tumors. Despite developm...

An odyssey of monoclonal gammopathies: focusing on precursors and the progression from MGUS and SMM to multiple Myeloma, with a brief overview of novel therapeutic strategies.

Monoclonal gammopathies span a continuum from monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) to overt...

Serum metabolomic signatures of relapse recovery in early multiple sclerosis.

BACKGROUND: Relapses in relapsing-remitting multiple sclerosis (RRMS) are acute neuroinflammatory events that shape long-term disease trajectory. Yet,...

AI-Enhanced Vibrational Capsule for Minimally Invasive Detection of Abnormal Bowel Tissue.

Colorectal cancer remains one of the leading causes of cancer mortality, and its prognosis is strongly dependent on early detection. Conventional diag...

Harnessing artificial intelligence in gastrointestinal endoscopy for early detection of dysplastic lesions in inflammatory bowel disease.

Artificial intelligence (AI) has become an increasingly valuable tool in gastrointestinal endoscopy, especially in the context of inflammatory bowel d...

CT-based subregional and peritumoral radiomics for predicting pathological T stage of clear cell renal cell carcinoma: an exploratory study of biological mechanisms.

OBJECTIVES: To evaluate intratumoral subregional and peritumoral radiomics for predicting pathological T stage of clear cell renal cell carcinoma (ccR...

Small-bowel capsule endoscopy - from clinic to couch: time to go green?

PURPOSE OF REVIEW: Small-bowel capsule endoscopy (SBCE) has transformed small-intestine diagnostics by enabling direct, noninvasive mucosal visualizat...

Outcomes of Artificial Intelligence Enhanced Colonoscopy in a Tertiary Clinical Setting.

BACKGROUND AND AIMS: Colonoscopies reduce colorectal cancer incidence and mortality, but challenges remain in detecting all precancerous lesions. Oper...

Primary infliximab failure in pediatric colonic inflammatory bowel disease: Development of a proteomics predictive model using a prospective Canadian cohort.

BACKGROUND: We aimed to build a serum proteomics-based model to predict primary nonresponse (PNR) to infliximab (IFX) in pediatric colonic inflammator...

Multimodal machine learning models for predicting remission in major depressive disorder using clinical data, blood biomarkers, and DNA methylation.

Major depressive disorder (MDD) is a leading global health burden, yet only one-third of patients achieve remission with initial antidepressant therap...

Artificial Intelligence for Gastroenterology Practice: A Modified Delphi Consensus.

BACKGROUND: The American College of Gastroenterology (ACG) assembled a multidisciplinary task force to evaluate the current state and future direction...

Toward Integration of Molecular Measures and Artificial Intelligence-Based Assessments With Clinical End Points in Inflammatory Bowel Disease.

Multimodal profiling of inflammatory bowel disease (IBD) patient tissue and blood samples has revealed the disease spectrum in unprecedented detail, a...