Nephrology

Outcome of kidney function in adults on long-term home parenteral nutrition for chronic intestinal failure.

OBJECTIVE: The aim of this study was to evaluate kidney function outcome in adults on home parenteral nutrition (HPN) for chronic intestinal failure using the newly recommended equations for estimated glomerular filtration rate (eGFR) assessment in clinical practice.

Progress in the Development and Challenges for the Use of Artificial Kidneys and Wearable Dialysis Devices.

BACKGROUND: Renal transplantation is the treatment of choice for chronic kidney disease (CKD) patients, but the shortage of kidneys and the disabling medical conditions these patients suffer from make dialysis essential for most of them. Since dialysis drastically affects the patients' lifestyle, there are great expectations for the development of wearable artificial kidneys, although their use is...

Artificial Intelligence and Dialysis.

Changes of Early Sepsis Biomarker Presepsin Level during Hemodialysis: Influence of β-Microglobulin Clearance of Dialysis Membrane: A Preliminary Study.

BACKGROUND: Although presepsin (P-SEP) is an early sepsis biomarker, sepsis is often suspected after starting hemodialysis (HD). To enhance the utilit...

Diagnosis of T-cell-mediated kidney rejection in formalin-fixed, paraffin-embedded tissues using RNA-Seq-based machine learning algorithms.

Molecular diagnosis is being increasingly used in transplant pathology to render more objective and quantitative determinations that also provide mech...

Critically Ill Recipients of Weight-Based Fluconazole Meeting Drug-Induced Liver Injury Network Criteria.

Fluconazole-associated liver injury is estimated to occur in <10% of patients; however, effect of weight-based fluconazole dosing on liver injury is ...

Automatic glomerular identification and quantification of histological phenotypes using image analysis and machine learning.

Current methods of scoring histological kidney samples, specifically glomeruli, do not allow for collection of quantitative data in a high-throughput ...

Validation of a low-dose contrast 64-slice cardiac computed tomography angiography protocol for aortic valve annulus sizing.

Cardiac computed tomography angiography (CCTA) is the gold standard for accurately sizing the aortic valve annulus prior to aortic valve replacement. ...

Second branchial cleft anomalies in children: a literature review.

Branchial cleft anomalies are the second most common head and neck congenital lesions in children. It may sometimes be a part of branchio-oto-renal (B...

Machine learning reveals chronic graft--host disease phenotypes and stratifies survival after stem cell transplant for hematologic malignancies.

The application of machine learning in medicine has been productive in multiple fields, but has not previously been applied to analyze the complexity ...

Wearable artificial kidney and wearable ultrafiltration device vascular access-future directions.

BACKGROUND: Since 2005, three human clinical trials have been performed with the Wearable Artificial Kidney (WAK) and Wearable Ultrafiltration (WUF) d...

PBN11-8, a Cytotoxic Polypeptide Purified from Marine , Suppresses Invasion and Migration of Human Hepatocellular Carcinoma Cells by Targeting Focal Adhesion Kinase Pathways.

The development of antitumor drugs has attracted cancer researchers and the identification of novel antitumor lead compounds is certainly of great int...

Morphometric Evaluation of the Seminiferous Tubules and the Antioxidant Protective Effects of Gallic Acid and Quercetin in the Testis and Liver of Butyl Phthalate Treated Rats.

The antioxidant protective effects of gallic acid (GAL) and quercetin (QUE) against oxidative stress induced by di-butyl phthalate (DnBP) in the liver...

A dynamic model for predicting graft function in kidney recipients' upcoming follow up visits: A clinical application of artificial neural network.

BACKGROUND: Predicting the function of transplanted kidneys would help clinicians in individualized medical interventions. We aimed to develop and val...

Fibroblast growth factor23 is associated with axonal integrity and neural network architecture in the human frontal lobes.

Elevated levels of FGF23 in individuals with chronic kidney disease (CKD) are associated with adverse health outcomes, such as increased mortality, la...

Societal Issues Concerning the Application of Artificial Intelligence in Medicine.

BACKGROUND: Medicine is becoming an increasingly data-centred discipline and, beyond classical statistical approaches, artificial intelligence (AI) an...

Clear Cell Renal Cell Carcinoma: Machine Learning-Based Quantitative Computed Tomography Texture Analysis for Prediction of Fuhrman Nuclear Grade.

OBJECTIVE: To evaluate the performance of quantitative computed tomography (CT) texture analysis using different machine learning (ML) classifiers for...

Disease Specific Ontology of Adverse Events: Ontology extension and adaptation for Chronic Kidney Disease.

BACKGROUND: Adverse Event (AE) ontology can be used to support interoperability and computer-assisted reasoning of AEs. Despite significant progress i...

Ethambutol-induced optic neuropathy in renal disorder: a clinico-electrophysiological study.

OBJECTIVE: To report the spectrum of ethambutol induced optic neuropathy in a group of renal patients with tuberculosis and the role of visual evoked ...

RASPELD to Perform High-End Screening in an Academic Environment toward the Development of Cancer Therapeutics.

The identification of compounds for dissecting biological functions and the development of novel drug molecules are central tasks that often require s...