Latest AI and machine learning research in oncology/hematology for healthcare professionals.
One of the important regulators of cellular iron uptake is transferrin receptor 1 (TFRC), which is closely linked to ferroptosis, an iron-dependent form of regulated cell death caused by lipid peroxidation. TFRC and ferroptosis-related biomarkers (including soluble transferrin receptor, labile iron pools, 4-hydroxynonenal, malondialdehyde, glutathione status, GPX4 expression, and oxidized species ...
BACKGROUND: The clinical management of glioma is increasingly dependent on the tumor's molecular profile, particularly the mutation status of Isocitrate Dehydrogenase (IDH), the promoter methylation of O-6-Methylguanine-DNA Methyltransferase (MGMT), and the co-deletion of chromosomal arms 1p and 19q. Determining these markers requires invasive tissue sampling. This study aimed to develop and valid...
Background With the widespread availability of whole-slide imaging, many studies have utilized digital images of hematoxylin and eosin (H&E)-stained b...
Gastric cancer is a leading cause of mortality worldwide, yet the development of computer-aided diagnosis (CAD) systems for its early detection is hin...
In patients with advanced high-grade serous ovarian carcinoma (HGSOC), the standard treatment typically involves platinum-based chemotherapy after deb...
PURPOSE: Accurate prediction of recurrence risk is crucial for personalizing therapy in human epidermal growth factor receptor 2-positive (HER2-positi...
BACKGROUND: Liquid-liquid phase separation (LLPS) dysregulation is a key driver of oncogenesis, yet its specific role in HPV-positive cervical cancer ...
BACKGROUND: To investigate the use of contrast-enhanced mammography (CEM) for preoperative prediction of lymphovascular invasion (LVI) status in invas...
BACKGROUND: The introduction of neoadjuvant and perioperative immunotherapy has broadened treatment options for resectable non-small cell lung cancer ...
BACKGROUND: Long-term androgen deprivation therapy (LT-ADT) with radiotherapy is standard-of-care for high-risk localized prostate cancer, with abirat...
Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive non-Hodgkin lymphoma and is characterized by substantial heterogeneity. This study...
INTRODUCTION: Evidence guiding the optimal sequencing of later-line systemic therapy in advanced soft tissue sarcoma (STS) remains limited. The aim of...
OBJECTIVE: We compared three magnetic resonance imaging (MRI) sequences-native zero echo time (ZTE), deep learning (DL)-chemical shift correction (CSC...
This mini-review synthesizes evidence from recent studies to provide an updated perspective on current applications, methodological challenges, and fu...
BACKGROUND AND PURPOSE: Radiation dermatitis (RD) and superficial soft tissue fibrosis are common toxicities among the patients with breast cancer rec...
Two-photon microscopy enables the non-invasive imaging of deep living tissue. Quantitative three-dimensional analysis is hampered by axial blur and an...
OBJECTIVE: Our goal was to develop a simulation platform for photon-counting CT (PCCT) imaging in mouse models of head and neck squamous cell carcinom...
CONTEXT.—: Breast-conserving surgery (BCS) offers comparable overall survival rates to mastectomy. However, 14% to 37% of cases require re-excision ow...
Leucine-rich-repeat-containing protein 15 (LRRC15) is selectively expressed on cancer-associated fibroblasts (CAFs) and constitutes a promising biomar...
Targeting the intrinsically disordered N-terminal domain of the androgen receptor (AR-NTD) represents a promising strategy to overcome resistance in p...