Peptic Ulcer Disease

Targeting GLS and LPIN2 in renal fibroblasts: potential therapeutic targets for kidney stone disease identified by integrated multi-omics analysis.

Kidney stones (KS) are a common urological condition, the aetiology of which remains incompletely understood. This study aimed to investigate the key cell types involved in the formation of kidney stones and the molecular mechanisms associated with calcium metabolism. Single-cell and bulk RNA-seq datasets related to kidney stones were downloaded from the GEO database. Single-cell analysis was perf...

Simulating Reality and Transforming Endoscopic Education-Lessons from Esophageal Dilation.

Although endoscopic training has traditionally relied on mentorship and procedural volume to assess proficiency, the major gastroenterology societies have increasingly adopted competency-based assessment tools, including the Assessment of Competency in Endoscopy (ACE) and Direct Observation of Procedural Skills (DOPS), to provide a more objective evaluation of technical and cognitive skills. Despi...

Spiramycin (SPR) antibiotics degradation with WO3 photocatalyst and ML XGBoost model for process parameters screening.

The intensification of worldwide urbanization and industrial growth has led to a rise in the release of toxic substances into the environment. Antibio...

An interpretable multi-instance learning method for accurate differentiation of malignant and benign laryngeal lesions in laryngoscopy.

BACKGROUND: Laryngeal cancer is a significant global health issue with high mortality, and early diagnosis is critical for survival. Developing accura...

[Reflections on surgical management strategies for locally advanced gastric cancer after neoadjuvant immunotherapy].

Neoadjuvant immunotherapy is reshaping the treatment landscape of locally advanced gastric cancer (GC). The central clinical challenge has expanded fr...

CASP1 as a key autophagy-related gene in atherosclerosis: Identification by bioinformatics analysis and experimental validation.

OBJECTIVE: This study identified potential autophagy-related genes (ARGs) in atherosclerosis using bioinformatics strategies, aiming to explore novel ...

Comparative outcomes of balloon-expandable versus self-expanding transcatheter aortic valves: insights from a large-scale German registry.

BACKGROUND: While transcatheter aortic valve replacement (TAVR) has become an established alternative to surgical aortic valve replacement (SAVR), the...

Antimony- and NSAID-Induced Hepatotoxicity at the Molecular Crossroads: Redox, Inflammasome and Programmed Cell-Death Networks as Therapeutic Targets for Natural Hepatoprotective Agents.

Drug- and metal-induced liver damage (DILI/MILI) continues to be a predominant cause of acute hepatic failure globally, with two clinically significan...

Understanding the Experiences of Young People Living With Haemophilia-A UK Social Media Study.

INTRODUCTION: Haemophilia is a rare congenital bleeding disorder that presents significant physical and psychological challenges, especially for young...

Transformer-Based Deep Learning Framework for Automated Lesion Detection in Capsule Endoscopy: A Comparative Study With CNN Architectures.

GOALS: To compare a vision transformer with 2 convolutional neural network architectures for multiclass lesion classification in capsule endoscopy ima...

Clinical Utility of LLM-assisted Chart Review for the Detection of Bleeding Events.

INTRODUCTION: Red blood cell (RBC) transfusions are frequently administered in the intensive care unit (ICU) and are independently associated with inc...

VIGIL: Vision-Language Guided Multiple Instance Learning Framework for Ulcerative Colitis Histological Healing Prediction.

OBJECTIVE: Ulcerative colitis (UC) is characterized by chronic inflammation with alternating remission-relapse cycles, necessitating precise histologi...

Integrative machine learning and single-nucleus transcriptomics reveal MAPK-centered neuronal responses underlying the potential Alzheimer's disease risk of GenX.

Hexafluoropropylene oxide-dimer acid (GenX or HFPO-DA) is a novel per- and polyfluoroalkyl substance developed as a replacement for legacy compounds, ...

MINPP1, HES4 and SLCO5A1 as core signature genes mediating the effects of type 2 diabetes on coronary artery bypass grafting.

PURPOSE: This study aimed to identify the signature genes that mediate the effects of type 2 diabetes (T2D) on coronary artery bypass grafting (CABG),...

Stephania cepharantha Hayata (Baiyaozi) attenuates cirrhosis-associated intestinal barrier injury by restoring mitochondrial function and suppressing PI3K/AKT signaling.

ETHNOPHARMACOLOGICAL RELEVANCE: Baiyaozi, the dried tuberous root of Stephania cepharantha Hayata, has long been used in traditional Chinese medicine ...

Critical Care-Specific vs General-Purpose Large Language Models in Emergency Intensive Care Unit Diagnosis: Single-Center Retrospective Paired Comparative Study.

BACKGROUND: The emergency intensive care unit (EICU) manages the most critically ill patients, where rapid and accurate diagnosis is essential yet cha...

Real-world evidence on antibiotic use among privately insured beneficiaries in Saudi Arabia: a retrospective analysis of claims data.

OBJECTIVES: Inappropriate and broad-spectrum antibiotic use contributes to antimicrobial resistance (AMR) and higher healthcare costs. In Saudi Arabia...

Protein-protein interaction-mediated signaling networks in ischemic stroke: from molecular mechanisms to therapeutic strategies.

The pathological progression of ischemic stroke is driven by a dynamic signaling network mediated by protein-protein interactions (PPI) that involves ...

AI-Based Phenotyping of Atrial Fibrillation Through Generative Topographic Mapping: Prospective Murcia Atrial Fibrillation Project III Cohort Study.

BACKGROUND: The clinical heterogeneity of atrial fibrillation (AF) challenges current classifications and risk scores, limiting their real-world appli...

Artificial Intelligence based identification of druggability of essential hypothetical proteins in Plasmodium falciparum.

Malaria, caused by Plasmodium falciparum is a deadly disease and remains a global health concern. With the emergence of resistance to artemisinin; it ...