Prescriptions

Optoelectronic fowl adenovirus detection based on local electric field enhancement on graphene quantum dots and gold nanobundle hybrid.

An optoelectronic sensor is a rapid diagnostic tool that allows for an accurate, reliable, field-portable, low-cost device for practical applications. In this study, template-free In situ gold nanobundles (Au NBs) were fabricated on an electrode for optoelectronic sensing of fowl adenoviruses (FAdVs). Au NB film was fabricated on carbon electrodes working area using L(+) ascorbic acid, gold chrolo...

Identification and characterization of the structure-activity relationships involved in UGT1A1 inhibition by anthraquinone and dianthrone constituents of Polygonum multiflorum.

The adverse effects of Polygonum (P.) multiflorum, including abnormal bilirubin metabolism, are a serious public health issue. As uridine diphosphate (UDP)-glucuronosyltransferase 1A1 (UGT1A1) is the only enzyme responsible for bilirubin metabolism, we investigated the inhibitory effect of a P. multiflorum extract and 10 anthraquinone and dianthrone compounds on UGT1A1 in rat liver microsomes in v...

A Review of Computational Drug Repositioning Approaches.

Computational drug repositioning emerges as a new idea of drug discovery and development. Contrary to conventional routines, computational drug reposi...

Improvement of imprinting effect of ionic liquid molecularly imprinted polymers by use of a molecular crowding agent.

We aimed to improve the imprinting effect of ionic liquid molecularly imprinted polymers (MIPs) by use of a molecular crowding agent. The ionic liquid...

Epileptic Seizures Prediction Using Machine Learning Methods.

Epileptic seizures occur due to disorder in brain functionality which can affect patient's health. Prediction of epileptic seizures before the beginni...

Deep Gramulator: Improving Precision in the Classification of Personal Health-Experience Tweets with Deep Learning.

Health surveillance is an important task to track the happenings related to human health, and one of its areas is pharmacovigilance. Pharmacovigilance...

Development and validation of an HPLC-UV method for analysis of methylphenidate hydrochloride and loxapine succinate in an activated carbon disposal system.

Unused medications have the possibility of being abused, causing serious harm to individuals who were not prescribed the drug. The Food and Drug Admin...

Augmented reality for personalized nanomedicines.

As our understanding of onset and progress of diseases at the genetic and molecular level rapidly progresses, the potential of advanced technologies, ...

The Metabolic Response of Skeletal Muscle to Endurance Exercise Is Modified by the ACE-I/D Gene Polymorphism and Training State.

The insertion/deletion polymorphism in the gene for the regulator of vascular tone, angiotensin-converting enzyme (ACE), is the prototype of a genetic...

Differential Compound Prioritization via Bidirectional Selectivity Push with Power.

Effective in silico compound prioritization is a critical step to identify promising drug candidates in the early stages of drug discovery. Current co...

Protein-Protein Interaction Article Classification Using a Convolutional Recurrent Neural Network with Pre-trained Word Embeddings.

Curation of protein interactions from scientific articles is an important task, since interaction networks are essential for the understanding of biol...

How do walkers behave when crossing the way of a mobile robot that replicates human interaction rules?

Previous studies showed the existence of implicit interaction rules shared by human walkers when crossing each other. Especially, each walker contribu...

UPLC-MS/MS method for the simultaneous quantification of sofosbuvir, sofosbuvir metabolite (GS-331007) and daclatasvir in plasma of HIV/HCV co-infected patients.

Direct-acting antiviral agents (DAAs) represent the major advance in hepatitis C virus (HCV) infection treatment leading to extremely high eradication...

Initiation of labor analgesia with injection of local anesthetic through the epidural needle compared to the catheter.

BACKGROUND: The rationale for injection of epidural medications through the needle is to promote sooner onset of pain relief relative to dosing throug...

Development of Decision Forest Models for Prediction of Drug-Induced Liver Injury in Humans Using A Large Set of FDA-approved Drugs.

Drug-induced liver injury (DILI) presents a significant challenge to drug development and regulatory science. The FDA's Liver Toxicity Knowledge Base ...

Identification of genes related to proliferative diabetic retinopathy through RWR algorithm based on protein-protein interaction network.

Proliferative diabetic retinopathy (PDR) is one of the most common complications of diabetes and can lead to blindness. Proteomic studies have provide...

One-pot synthesis of glutathione-responsive amphiphilic drug self-delivery micelles of doxorubicin-disulfide-methoxy polyethylene glycol for tumor therapy.

We present a novel glutathione-responsive amphiphilic drug self-delivery (DSD) micelle with one-pot synthesis to synergistically address the problems ...

Supervised learning for infection risk inference using pathology data.

BACKGROUND: Antimicrobial Resistance is threatening our ability to treat common infectious diseases and overuse of antimicrobials to treat human infec...

Zinc-Modified Nanotransporter of Doxorubicin for Targeted Prostate Cancer Delivery.

This work investigated the preparation of chitosan nanoparticles used as carriers for doxorubicin for targeted cancer delivery. Prepared nanocarriers ...

Construction of a 26‑feature gene support vector machine classifier for smoking and non‑smoking lung adenocarcinoma sample classification.

The present study aimed to identify the feature genes associated with smoking in lung adenocarcinoma (LAC) samples and explore the underlying mechanis...