Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Feb 22, 2025
To evaluate the quality of artificial visual percepts generated by emerging methodologies, researchers often rely on labor-intensive and tedious human psychophysical experiments. These experiments necessitate repeated iterations upon any major/minor ...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Feb 17, 2025
Rapid and accurate differential diagnosis of infections, sepsis, and septic shock is essential for preventing unnecessary antibiotic overuse and improving the chance of patient survival. To address this, a 3D gold nanogranule decorated gold-silver al...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Feb 11, 2025
Identifying interactions between candidate antibodies and target antigens is a key step in developing effective human therapeutics. The antigen-antibody interaction (AAI)Â occurs at the structural level, but the limited structure data poses a signific...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Feb 11, 2025
Adeno-associated virus (AAV) has emerged as a leading vector for gene therapy due to its broad host range, low pathogenicity, and ability to facilitate long-term gene expression. However, AAV vectors face limitations, including immunogenicity and ins...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Feb 8, 2025
Novel antifungal drugs that evade resistance are urgently needed for Candida infections. Antifungal peptides (AFPs) are potential candidates due to their specific mechanism of action, which makes them less prone to developing drug resistance. An AFP ...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Feb 3, 2025
Unexpected toxicity has become a significant obstacle to drug candidate development, accounting for 30% of drug discovery failures. Traditional toxicity assessment through animal testing is costly and time-consuming. Big data and artificial intellige...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Feb 3, 2025
Legged robots, designed to emulate human functions, have greatly influenced numerous sectors. However, the focus on continuously improving the joint motors and control systems of existing legged robots not only increases costs and complicates mainten...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Jan 28, 2025
Efficient virtual screening methods can expedite drug discovery and facilitate the development of innovative therapeutics. This study presents a novel transfer learning model based on network target theory, integrating deep learning techniques with d...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Jan 24, 2025
Efficiently extracting data from tables in the scientific literature is pivotal for building large-scale databases. However, the tables reported in materials science papers exist in highly diverse forms; thus, rule-based extractions are an ineffectiv...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Jan 23, 2025
3D disordered fibrous network structures (3D-DFNS), such as cytoskeletons, collagen matrices, and spider webs, exhibit remarkable material efficiency, lightweight properties, and mechanical adaptability. Despite their widespread in nature, the integr...