Cerebral cortex (New York, N.Y. : 1991)
Jan 5, 2023
This study aimed to analyse cerebral grey matter changes in mild cognitive impairment (MCI) using voxel-based morphometry and to diagnose early Alzheimer's disease using deep learning methods based on convolutional neural networks (CNNs) evaluating t...
Cerebral cortex (New York, N.Y. : 1991)
Jan 22, 2022
Human perception and learning is thought to rely on a hierarchical generative model that is continuously updated via precision-weighted prediction errors (pwPEs). However, the neural basis of such cognitive process and how it unfolds during decision-...
Cerebral cortex (New York, N.Y. : 1991)
Jan 22, 2022
Mild cognitive impairment (MCI) is often considered the precursor of Alzheimer's disease. However, MCI is associated with substantially variable progression rates, which are not well understood. Attempts to identify the mechanisms that underlie MCI p...
Cerebral cortex (New York, N.Y. : 1991)
Jun 10, 2021
Here we assessed changes in subcortical volumes in alcohol use disorder (AUD). A simple morphometry-based classifier (MC) was developed to identify subcortical volumes that distinguished 32 healthy controls (HCs) from 33 AUD patients, who were scanne...
Cerebral cortex (New York, N.Y. : 1991)
Mar 5, 2021
During the execution of working memory tasks, task-relevant information is processed by local circuits across multiple brain regions. How this multiarea computation is conducted by the brain remains largely unknown. To explore such mechanisms in spat...
Cerebral cortex (New York, N.Y. : 1991)
Feb 5, 2021
The analysis of neural circuits can provide crucial insights into the mechanisms of neurodegeneration and dementias, and offer potential quantitative biological tools to assess novel therapeutics. Here we use behavioral variant frontotemporal dementi...
Cerebral cortex (New York, N.Y. : 1991)
Jan 5, 2021
Functional connectivity (FC) matrices measure the regional interactions in the brain and have been widely used in neurological brain disease classification. A brain network, also named as connectome, could form a graph structure naturally, the nodes ...
Cerebral cortex (New York, N.Y. : 1991)
Jan 5, 2021
Resting-state functional MRI (rs-fMRI) studies have revealed specific low-frequency hemodynamic signal fluctuations (<0.1 Hz) in the brain, which could be related to neuronal oscillations through the neurovascular coupling mechanism. Given the vascul...
Cerebral cortex (New York, N.Y. : 1991)
Jan 1, 2021
Accurate and automated reconstruction of the in vivo human cerebral cortical surface from anatomical magnetic resonance (MR) images facilitates the quantitative analysis of cortical structure. Anatomical MR images with sub-millimeter isotropic spatia...
Cerebral cortex (New York, N.Y. : 1991)
Oct 1, 2020
The aging process is accompanied by changes in the brain's cortex at many levels. There is growing interest in summarizing these complex brain-aging profiles into a single, quantitative index that could serve as a biomarker both for characterizing in...