Cytometry. Part A : the journal of the International Society for Analytical Cytology
Nov 5, 2019
High-throughput single-cell cytometry technologies have significantly improved our understanding of cellular phenotypes to support translational research and the clinical diagnosis of hematological and immunological diseases. However, subjective and ...
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Nov 5, 2019
Imaging flow cytometry (IFC) produces up to 12 spectrally distinct, information-rich images of single cells at a throughput of 5,000 cells per second. Yet often, cell populations are still studied using manual gating, a technique that has several dra...
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Oct 8, 2019
Building automated cancer screening systems based on image analysis is currently a hot topic in computer vision and medical imaging community. One of the biggest challenges of such systems, especially those using state-of-the-art deep learning techni...
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Aug 12, 2019
Pathological diagnosis plays an important role in the diagnosis and treatment of hepatocellular carcinoma (HCC). The traditional method of pathological diagnosis of most cancers requires freezing, slicing, hematoxylin and eosin staining, and manual a...
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Jul 16, 2019
We develop a single-mode fiber-based cytometer for the obtaining of two-dimensional (2D) light scattering patterns from static single cells. Anisotropy of the 2D light scattering patterns of single cells from ovarian cancer and normal cell lines is i...
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Jul 7, 2019
Minimal residual disease (MRD) as measured by multiparameter flow cytometry (FCM) is an independent and strong prognostic factor in B-cell acute lymphoblastic leukemia (B-ALL). However, reliable flow cytometric detection of MRD strongly depends on op...
Cytometry. Part A : the journal of the International Society for Analytical Cytology
May 17, 2019
Recent years have seen an increased interest in employing data analysis techniques for the automated identification of cell populations in the field of cytometry. These techniques highly depend on the use of a distance metric, a function that quantif...
Cytometry. Part A : the journal of the International Society for Analytical Cytology
May 13, 2019
White blood cell (WBC) differential counting is an established clinical routine to assess patient immune system status. Fluorescent markers and a flow cytometer are required for the current state-of-the-art method for determining WBC differential cou...
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Apr 22, 2019
Robust and reproducible profiling of cell lines is essential for phenotypic screening assays. The goals of this study were to determine robust and reproducible optical phase signatures of cell lines for classification with machine learning and to cor...
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Apr 8, 2019
Cell classification based on phenotypical, spatial, and genetic information greatly advances our understanding of the physiology and pathology of biological systems. Technologies derived from next generation sequencing and fluorescent activated cell ...