AI Medical Compendium Journal:
International journal of molecular sciences

Showing 31 to 40 of 423 articles

Comparative Study of Deep Transfer Learning Models for Semantic Segmentation of Human Mesenchymal Stem Cell Micrographs.

International journal of molecular sciences Mar 6, 2025
The aim of this study is to conduct a comparative assessment of the effectiveness of neural network models-U-Net, DeepLabV3+, SegNet and Mask R-CNN-for the semantic segmentation of micrographs of human mesenchymal stem cells (MSCs). A dataset of 320 ...
Semantics Deep Learning Image Processing, Computer-Assisted Mesenchymal Stem Cells Humans Neural Networks, Computer
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Insight into the Relationships Between Chemical, Protein and Functional Variables in the PBP/GOBP Family in Moths Based on Machine Learning.

International journal of molecular sciences Mar 5, 2025
During their lives, insects must cope with a plethora of chemicals, of which a few will have an impact at the behavioral level. To detect these chemicals, insects use several protein families located in their main olfactory organs, the antennae. Insi...
Receptors, Odorant Machine Learning Insect Proteins Animals Moths Carrier Proteins Algorithms
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miRNA-Based Diagnosis of Schizophrenia Using Machine Learning.

International journal of molecular sciences Mar 4, 2025
Diagnostic practices for schizophrenia are unreliable due to the lack of a stable biomarker. However, machine learning holds promise in aiding in the diagnosis of schizophrenia and other neurological disorders. Dysregulated miRNAs were extracted from...
Humans MicroRNAs Bayes Theorem Neural Networks, Computer Schizophrenia Machine Learning Biomarkers
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Therapeutic Mechanisms of Medicine Food Homology Plants in Alzheimer's Disease: Insights from Network Pharmacology, Machine Learning, and Molecular Docking.

International journal of molecular sciences Feb 27, 2025
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by a gradual decline in cognitive function. Currently, there are no effective treatments for this condition. Medicine food homology plants have gained increasing atten...
Alzheimer Disease Network Pharmacology Molecular Docking Simulation Humans STAT3 Transcription Factor Plants, Medicinal Machine Learning
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Machine Learning Methods for Classifying Multiple Sclerosis and Alzheimer's Disease Using Genomic Data.

International journal of molecular sciences Feb 27, 2025
Complex diseases pose challenges in prediction due to their multifactorial and polygenic nature. This study employed machine learning (ML) to analyze genomic data from the UK Biobank, aiming to predict the genomic predisposition to complex diseases l...
Polymorphism, Single Nucleotide Alzheimer Disease Multiple Sclerosis Genomics Genetic Predisposition to Disease Multifactorial Inheritance Quantitative Trait Loci Linkage Disequilibrium Humans Machine Learning
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SERPINA3: A Novel Therapeutic Target for Diabetes-Related Cognitive Impairment Identified Through Integrated Machine Learning and Molecular Docking Analysis.

International journal of molecular sciences Feb 24, 2025
Diabetes-related cognitive impairment (DCI) is a severe complication of type 2 diabetes mellitus (T2DM), with limited understanding of its molecular mechanisms hindering effective therapeutic development. This study identified SERPINA3 as a potential...
Cognitive Dysfunction Humans Diabetes Mellitus, Type 2 Machine Learning Sulfonylurea Compounds Serpins Hypoglycemic Agents Male Female Middle Aged Aged Molecular Docking Simulation
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Mediation CNN (Med-CNN) Model for High-Dimensional Mediation Data.

International journal of molecular sciences Feb 20, 2025
Complex biological features such as the human microbiome and gene expressions play a crucial role in human health by mediating various biomedical processes that influence disease progression, such as immune responses and metabolic processes. Understa...
Algorithms Humans Computer Simulation Neural Networks, Computer Microbiota
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Machine Learning-Aided Optimization of In Vitro Tetraploid Induction in Cannabis.

International journal of molecular sciences Feb 18, 2025
Polyploidy, characterized by an increase in the number of whole sets of chromosomes in an organism, offers a promising avenue for cannabis improvement. Polyploid cannabis plants often exhibit altered morphological, physiological, and biochemical char...
Dinitrobenzenes Polyploidy Neural Networks, Computer Tetraploidy Machine Learning Cannabis Sulfanilamides Algorithms
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Graph and Multi-Level Sequence Fusion Learning for Predicting the Molecular Activity of BACE-1 Inhibitors.

International journal of molecular sciences Feb 16, 2025
The development of BACE-1 (β-site amyloid precursor protein cleaving enzyme 1) inhibitors is a crucial focus in exploring early treatments for Alzheimer's disease (AD). Recently, graph neural networks (GNNs) have demonstrated significant advantages i...
Aspartic Acid Endopeptidases Neural Networks, Computer Machine Learning Enzyme Inhibitors Amyloid Precursor Protein Secretases Alzheimer Disease Humans
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Exploring Potential Medications for Alzheimer's Disease with Psychosis by Integrating Drug Target Information into Deep Learning Models: A Data-Driven Approach.

International journal of molecular sciences Feb 14, 2025
Approximately 50% of Alzheimer's disease (AD) patients develop psychotic symptoms, leading to a subtype known as psychosis in AD (AD + P), which is associated with accelerated cognitive decline compared to AD without psychosis. Currently, no FDA-appr...
Electronic Health Records Female Aged Humans Psychotic Disorders Alzheimer Disease Antipsychotic Agents Male Deep Learning
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