Laboratory investigation; a journal of technical methods and pathology
Aug 13, 2024
Tumor-stroma ratio (TSR) has been recognized as a valuable prognostic indicator in various solid tumors. This study aimed to examine the clinicopathologic relevance of TSR in Merkel cell carcinoma (MCC) using artificial intelligence (AI)-based parame...
Laboratory investigation; a journal of technical methods and pathology
Jul 23, 2024
The advent of affordable technology has significantly influenced the practice of digital pathology, leading to its growing adoption within the pathology community. This review article aimed to outline the latest developments in digital pathology, the...
Laboratory investigation; a journal of technical methods and pathology
Jun 24, 2024
In our rapidly expanding landscape of artificial intelligence, synthetic data have become a topic of great promise and also some concern. This review aimed to provide pathologists and laboratory professionals with a primer on the role of synthetic da...
Laboratory investigation; a journal of technical methods and pathology
Jun 11, 2024
Accurate assessment of epidermal growth factor receptor (EGFR) mutation status and subtype is critical for the treatment of non-small cell lung cancer patients. Conventional molecular testing methods for detecting EGFR mutations have limitations. In ...
Laboratory investigation; a journal of technical methods and pathology
Apr 26, 2024
Immunohistochemistry (IHC) is used to guide treatment decisions in multiple cancer types. For treatment with checkpoint inhibitors, programmed death ligand 1 (PD-L1) IHC is used as a companion diagnostic. However, the scoring of PD-L1 is complicated ...
Laboratory investigation; a journal of technical methods and pathology
Feb 29, 2024
This review aims to present a comprehensive overview of the current landscape of artificial intelligence (AI) applications in the analysis of tubular gastrointestinal biopsies. These publications cover a spectrum of conditions, ranging from inflammat...
Laboratory investigation; a journal of technical methods and pathology
Sep 26, 2023
Digital pathology has transformed the traditional pathology practice of analyzing tissue under a microscope into a computer vision workflow. Whole-slide imaging allows pathologists to view and analyze microscopic images on a computer monitor, enablin...
Laboratory investigation; a journal of technical methods and pathology
Sep 22, 2023
Epithelial ovarian cancer (EOC) remains a significant cause of mortality among gynecologic cancers, with the majority of cases being diagnosed at an advanced stage. Before targeted therapies were available, EOC treatment relied largely on debulking s...
Laboratory investigation; a journal of technical methods and pathology
Mar 6, 2023
Neuropathologic assessment during autopsy is the gold standard for diagnosing neurodegenerative disorders. Neurodegenerative conditions, such as Alzheimer disease (AD) neuropathological change, are a continuous process from normal aging rather than c...
Laboratory investigation; a journal of technical methods and pathology
Jan 10, 2023
A morphologic examination is essential for the diagnosis of hematological diseases. However, its conventional manual operation is time-consuming and laborious. Herein, we attempt to establish an artificial intelligence (AI)-aided diagnostic framework...