Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Dec 1, 2023
Immunohistochemistry (IHC) is a well-established and commonly used staining method for clinical diagnosis and biomedical research. In most IHC images, the target protein is conjugated with a specific antibody and stained using diaminobenzidine (DAB),...
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Nov 7, 2023
Breast cancer is one of the most common cancers affecting women worldwide. It includes a group of malignant neoplasms with a variety of biological, clinical, and histopathologic characteristics. There are more than 35 different histologic forms of br...
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Nov 4, 2023
Conventional histopathology involves expensive and labor-intensive processes that often consume tissue samples, rendering them unavailable for other analyses. We present a novel end-to-end workflow for pathology powered by hyperspectral microscopy an...
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Nov 3, 2023
The current flow cytometric analysis of blood and bone marrow samples for diagnosis of acute myeloid leukemia (AML) relies heavily on manual intervention in the processing and analysis steps, introducing significant subjectivity into resulting diagno...
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Oct 10, 2023
Recent progress in computational pathology has been driven by deep learning. While code and data availability are essential to reproduce findings from preceding publications, ensuring a deep learning model's reusability is more challenging. For that,...
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Sep 15, 2023
Microscopic evaluation of glands in the colon is of utmost importance in the diagnosis of inflammatory bowel disease and cancer. When properly trained, deep learning pipelines can provide a systematic, reproducible, and quantitative assessment of dis...
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Sep 6, 2023
Digital pathology adoption allows for applying computational algorithms to routine pathology tasks. Our study aimed to develop a clinical-grade artificial intelligence (AI) tool for precise multiclass tissue segmentation in colorectal specimens (rese...
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Aug 29, 2023
The etiology of head and neck squamous cell carcinoma (HNSCC) involves multiple carcinogens, such as alcohol, tobacco, and infection with human papillomavirus (HPV). Because HPV infection influences the prognosis, treatment, and survival of patients ...
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Aug 26, 2023
We developed a deep learning framework to accurately predict the lymph node status of patients with cervical cancer based on hematoxylin and eosin-stained pathological sections of the primary tumor. In total, 1524 hematoxylin and eosin-stained whole ...
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Aug 12, 2023
Neoadjuvant therapies are used for locally advanced non-small cell lung carcinomas, whereby pathologists histologically evaluate the effect using resected specimens. Major pathological response (MPR) has recently been used for treatment evaluation an...