INTRODUCTION: Parkinson's disease (PD) is a progressive neurodegenerative disorder marked by diverse motor and non-motor symptoms. AI appears to be the elephant in the neurologist's room, albeit offering transformative potential in early diagnosis, p...
INTRODUCTION: The World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) is a well-known measure to assess disability in persons with Parkinson's disease (PD). The purpose of this study was to develop a short form of the WHODAS 2.0...
BACKGROUND: Previous studies have used machine learning to identify clinically relevant atrophic regions in progressive supranuclear palsy (PSP). This study applied Elastic Net (EN) in PSP to uncover key atrophic patterns, offering a novel approach t...
BACKGROUND: Parkinson's disease (PD) is a major neurodegenerative disorder in Middle-aged and elderly people.There is a pressing need for effective predictive models, particularly in chinese population.
BACKGROUND: Evaluation of disease severity in Parkinson's disease (PD) relies on motor symptoms quantification. However, during early-stage PD, these symptoms are subtle and difficult to quantify by experts, which might result in delayed diagnosis an...
BACKGROUND: Prolonged levodopa treatment in Parkinson's disease (PD) often leads to motor complications, including levodopa-induced dyskinesia (LID). Despite continuous levodopa treatment, some patients do not develop LID symptoms, even in later stag...
Parkinson's disease is a neurodegenerative movement disorder associated with motor and non-motor symptoms causing severe disability as the disease progresses. The development of biomarkers for Parkinson's disease to diagnose patients earlier and pred...
BACKGROUND: Mild cognitive impairment in Parkinson's disease (PD-MCI) includes deficits in different cognitive domains, and one domain to explore for neurocognitive impairment following the DSM-V is social cognition. However, this domain is not inclu...
BACKGROUND: Essential tremor (ET) and dystonic tremor (DT) are the two most common tremor disorders, and misdiagnoses are very common due to similar tremor symptoms. In this study, we explore the structural network mechanisms of ET and DT using brain...
INTRODUCTION: Differentiating Progressive Supranuclear Palsy (PSP) from Parkinson's Disease (PD) may be clinically challenging. In this study, we explored the performance of machine learning models based on MR imaging and blood molecular biomarkers i...