AIMC Topic: Adaptive Immunity

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To err is robotic, to tolerate immunological: fault detection in multirobot systems.

Bioinspiration & biomimetics Feb 2, 2015
Fault detection and fault tolerance represent two of the most important and largely unsolved issues in the field of multirobot systems (MRS). Efficient, long-term operation requires an accurate, timely detection, and accommodation of abnormally behav...
Adaptive Immunity Algorithms Equipment Failure Analysis Computer Simulation Models, Immunological Humans Robotics Biomimetics Animals Equipment Failure
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Simulation of adaptive immune receptors and repertoires with complex immune information to guide the development and benchmarking of AIRR machine learning.

Nucleic acids research Jan 24, 2025
Machine learning (ML) has shown great potential in the adaptive immune receptor repertoire (AIRR) field. However, there is a lack of large-scale ground-truth experimental AIRR data suitable for AIRR-ML-based disease diagnostics and therapeutics disco...
Humans Machine Learning Benchmarking Receptors, Immunologic Adaptive Immunity Software Computer Simulation
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Predicting adaptive immune receptor specificities by machine learning is a data generation problem.

Cell systems Dec 18, 2024
Determining the specificity of adaptive immune receptors-B cell receptors (BCRs), their secreted form antibodies, and T cell receptors (TCRs)-is critical for understanding immune responses and advancing immunotherapy and drug discovery. Immune recept...
Animals Receptors, Antigen, T-Cell Humans Machine Learning Receptors, Antigen, B-Cell Receptors, Immunologic Adaptive Immunity
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Reading the repertoire: Progress in adaptive immune receptor analysis using machine learning.

Cell systems Dec 18, 2024
The adaptive immune system holds invaluable information on past and present immune responses in the form of B and T cell receptor sequences, but we are limited in our ability to decode this information. Machine learning approaches are under active in...
Machine Learning Software Receptors, Immunologic Animals Adaptive Immunity Receptors, Antigen, T-Cell Humans
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High-dimensional profiling clusters asthma severity by lymphoid and non-lymphoid status.

Cell reports Apr 13, 2021
Clinical definitions of asthma fail to capture the heterogeneity of immune dysfunction in severe, treatment-refractory disease. Applying mass cytometry and machine learning to bronchoalveolar lavage (BAL) cells, we find that corticosteroid-resistant ...
Interleukin-7 Receptors, IgE Adaptive Immunity Immunologic Memory Interferon-gamma Bronchoalveolar Lavage Fluid Adrenal Cortex Hormones Anti-Asthmatic Agents CD4-Positive T-Lymphocytes Gene Expression Regulation Immunity, Innate CD8-Positive T-Lymphocytes Severity of Illness Index Gene Expression Profiling Proteomics Signal Transduction Case-Control Studies Humans Macrophages Machine Learning Asthma Interleukin-10
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Enhancement of the Immune Function by Titanium Dioxide Nanorods and Their Application in Cancer Immunotherapy.

Journal of biomedical nanotechnology Apr 1, 2017
With the rapid development of nanotherapy, concerns surrounding the possible use of nanomaterials-mediated immunomodulation are growing. Thus, evaluating the effects of novel materials for potential application in nanotherapy is essential. Herein, we...
Adaptive Immunity Nanotubes Dose-Response Relationship, Drug Titanium Mice Neoplasms, Experimental Animals Immunotherapy Cell Line, Tumor Treatment Outcome Cytokines Mice, Inbred BALB C Female
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