AIMC Topic: Immunologic Memory

Clear Filters Showing 1 to 4 of 4 articles

Trained Immunity: RoadMap for drug discovery and development.

eLife Dec 23, 2025
Trained Immunity is the nonspecific (pathogen agnostic) memory of innate immune cells, characterized by altered responses upon secondary stimulation. This review provides a RoadMap for the discovery and development of therapeutics targeting Trained I...
Animals Drug Discovery Humans Artificial Intelligence Immunologic Memory Trained Immunity Drug Development Immunity, Innate
View on PubMed DOI

Prediction and characterisation of the human B cell response to a heterologous two-dose Ebola vaccine.

Nature communications Jul 9, 2025
Ebola virus disease (EVD) outbreaks are increasing, posing significant threats to affected communities. Effective outbreak management depends on protecting frontline health workers, a key focus of EVD vaccination strategies. IgG specific to the viral...
Humans Machine Learning Single-Cell Analysis Antibodies, Viral Immunoglobulin G Female Plasma Cells Ebola Vaccines Ebolavirus Immunologic Memory Hemorrhagic Fever, Ebola Receptors, Antigen, B-Cell Vaccination B-Lymphocytes
View on PubMed DOI

Sensitive detection of rare disease-associated cell subsets via representation learning.

Nature communications Apr 6, 2017
Rare cell populations play a pivotal role in the initiation and progression of diseases such as cancer. However, the identification of such subpopulations remains a difficult task. This work describes CellCnn, a representation learning approach to de...
Supervised Machine Learning Survival Analysis Acquired Immunodeficiency Syndrome Cytomegalovirus Infections Immunologic Memory Rare Diseases Leukemia Prognosis Neoplasm, Residual Single-Cell Analysis Neural Networks, Computer Humans Killer Cells, Natural Cytokines Monocytes T-Lymphocyte Subsets Signal Transduction
View on PubMed DOI

High-dimensional profiling clusters asthma severity by lymphoid and non-lymphoid status.

Cell reports Apr 13, 2021
Clinical definitions of asthma fail to capture the heterogeneity of immune dysfunction in severe, treatment-refractory disease. Applying mass cytometry and machine learning to bronchoalveolar lavage (BAL) cells, we find that corticosteroid-resistant ...
Interleukin-7 Receptors, IgE Adrenal Cortex Hormones Anti-Asthmatic Agents Adaptive Immunity Immunologic Memory Interferon-gamma Bronchoalveolar Lavage Fluid Gene Expression Regulation Machine Learning Interleukin-10 Macrophages Asthma Humans Signal Transduction Immunity, Innate CD8-Positive T-Lymphocytes Case-Control Studies CD4-Positive T-Lymphocytes Proteomics Severity of Illness Index Gene Expression Profiling
View on PubMed DOI
Popular Topics
Recent Journals