AIMC Topic: Immunologic Memory

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Prediction and characterisation of the human B cell response to a heterologous two-dose Ebola vaccine.

Nature communications Jul 9, 2025
Ebola virus disease (EVD) outbreaks are increasing, posing significant threats to affected communities. Effective outbreak management depends on protecting frontline health workers, a key focus of EVD vaccination strategies. IgG specific to the viral...
Ebolavirus Hemorrhagic Fever, Ebola B-Lymphocytes Plasma Cells Ebola Vaccines Receptors, Antigen, B-Cell Single-Cell Analysis Immunologic Memory Female Vaccination Antibodies, Viral Humans Machine Learning Immunoglobulin G
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Sensitive detection of rare disease-associated cell subsets via representation learning.

Nature communications Apr 6, 2017
Rare cell populations play a pivotal role in the initiation and progression of diseases such as cancer. However, the identification of such subpopulations remains a difficult task. This work describes CellCnn, a representation learning approach to de...
Immunologic Memory Acquired Immunodeficiency Syndrome Neoplasm, Residual Cytomegalovirus Infections Leukemia Signal Transduction Neural Networks, Computer Rare Diseases Prognosis Killer Cells, Natural Cytokines Monocytes Humans T-Lymphocyte Subsets Single-Cell Analysis Survival Analysis Supervised Machine Learning
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High-dimensional profiling clusters asthma severity by lymphoid and non-lymphoid status.

Cell reports Apr 13, 2021
Clinical definitions of asthma fail to capture the heterogeneity of immune dysfunction in severe, treatment-refractory disease. Applying mass cytometry and machine learning to bronchoalveolar lavage (BAL) cells, we find that corticosteroid-resistant ...
Adrenal Cortex Hormones Anti-Asthmatic Agents Bronchoalveolar Lavage Fluid Interleukin-7 Receptors, IgE Immunologic Memory Adaptive Immunity CD4-Positive T-Lymphocytes Interferon-gamma Gene Expression Regulation Immunity, Innate CD8-Positive T-Lymphocytes Signal Transduction Machine Learning Humans Gene Expression Profiling Macrophages Severity of Illness Index Proteomics Case-Control Studies Asthma Interleukin-10
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