AIMC Topic: Aging

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Signed Curvature Graph Representation Learning of Brain Networks for Brain Age Estimation.

IEEE journal of biomedical and health informatics
Graph Neural Networks (GNNs) play a pivotal role in learning representations of brain networks for estimating brain age. However, the over-squashing impedes interactions between long-range nodes, hindering the ability of message-passing mechanism-bas...

Validation requirements for AI-based intervention-evaluation in aging and longevity research and practice.

Ageing research reviews
The field of aging and longevity research is overwhelmed by vast amounts of data, calling for the use of Artificial Intelligence (AI), including Large Language Models (LLMs), for the evaluation of geroprotective interventions. Such evaluations should...

Discovering geroprotectors through the explainable artificial intelligence-based platform AgeXtend.

Nature aging
Aging involves metabolic changes that lead to reduced cellular fitness, yet the role of many metabolites in aging is unclear. Understanding the mechanisms of known geroprotective molecules reveals insights into metabolic networks regulating aging and...

Evaluating the reproducibility of a deep learning algorithm for the prediction of retinal age.

GeroScience
Recently, a deep learning algorithm (DLA) has been developed to predict the chronological age from retinal images. The Retinal Age Gap (RAG), a deviation between predicted age from retinal images (Retinal Age, RA) and chronological age, correlates wi...

Insights to aging prediction with AI based epigenetic clocks.

Epigenomics
Over the past century, human lifespan has increased remarkably, yet the inevitability of aging persists. The disparity between biological age, which reflects pathological deterioration and disease, and chronological age, indicative of normal aging, h...

Social Robots and Sensors for Enhanced Aging at Home: Mixed Methods Study With a Focus on Mobility and Socioeconomic Factors.

JMIR aging
BACKGROUND: Population aging affects society, with a profound impact on daily activities for those of a low socioeconomic status and with motor impairments. Social assistive robots (SARs) and monitoring technologies can improve older adults' well-bei...

Machine learning based on event-related oscillations of working memory differentiates between preclinical Alzheimer's disease and normal aging.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
OBJECTIVE: To apply machine learning approaches on EEG event-related oscillations (ERO) to discriminate preclinical Alzheimer's disease (AD) from age- and sex-matched controls.

An interactive AI-driven platform for fish age reading.

PloS one
Fish age is an important biological variable required as part of routine stock assessment and analysis of fish population dynamics. Age estimates are traditionally obtained by human experts from the count of ring-like patterns along calcified structu...

Artificial intelligence modeling of biomarker-based physiological age: Impact on phase 1 drug-metabolizing enzyme phenotypes.

CPT: pharmacometrics & systems pharmacology
Age and aging are important predictors of health status, disease progression, drug kinetics, and effects. The purpose was to develop ensemble learning-based physiological age (PA) models for evaluating drug metabolism. National Health and Nutrition E...

Explaining deep learning models for age-related gait classification based on acceleration time series.

Computers in biology and medicine
BACKGROUND: Gait analysis holds significant importance in monitoring daily health, particularly among older adults. Advancements in sensor technology enable the capture of movement in real-life environments and generate big data. Machine learning, no...