Proteome changes associated with APOE4 variant carriage that are independent of Alzheimer's disease (AD) pathology and diagnosis are unknown. This study investigated APOE4 proteome changes in people with AD, mild cognitive impairment, and no impairme...
Alzheimer's Disease (AD) is a debilitating neurodegenerative disease that affects 47.5 million people worldwide. AD is characterised by the formation of plaques containing extracellular amyloid-β (Aβ) and neurofibrillary tangles composed of hyper-pho...
BACKGROUND: To diagnose Alzheimer disease (AD), individuals are classified according to the severity of their cognitive impairment. There are currently no specific causes or conditions for this disease.
Neural networks : the official journal of the International Neural Network Society
Dec 20, 2024
Correctly diagnosing Alzheimer's disease (AD) and identifying pathogenic brain regions and genes play a vital role in understanding the AD and developing effective prevention and treatment strategies. Recent works combine imaging and genetic data, an...
The disease amyloid plaques, neurofibrillary tangles, synaptic dysfunction, and neuronal death gradually accumulate throughout Alzheimer's disease (AD), resulting in cognitive decline and functional disability. The challenges of dataset quality, inte...
Alzheimer's disease (AD), the most common neurodegenerative disorder world-wide, presents sex-specific differences in its manifestation and progression, necessitating personalized diagnostic approaches. Current procedures are often costly and invasiv...
BACKGROUND: Alzheimer's Disease is a neurodegenerative condition leading to irreversible and progressive brain damage, with possible features such as structural atrophy. Effective precision diagnosis is crucial for slowing disease progression and red...
International journal of molecular sciences
Dec 15, 2024
The overlapping molecular pathophysiology of Alzheimer's Disease (AD), Amyotrophic Lateral Sclerosis (ALS), and Frontotemporal Dementia (FTD) was analyzed using relationships from a knowledge graph of 33+ million biomedical journal articles. The unsu...
Alzheimer's dementia (AD) is a neurodegenerative disorder that affects the central nervous system, causing the cells to stop working or die. The quality of life for individuals with AD steadily declines over time. While current treatments can relieve...
BACKGROUND: Alzheimer's Disease (AD) poses a major challenge as a neurodegenerative disorder, and early detection is critical for effective intervention. Magnetic resonance imaging (MRI) is a critical tool in AD research due to its availability and c...
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