Alzheimer's disease is a major cause of dementia in older adults. It involves gradual changes in brain function that result in cognitive decline, affecting memory, reasoning, and executive skills. The accurate detection of structural abnormalities in...
BACKGROUND: Alzheimer's disease (AD) is a progressive neurodegenerative disorder with complex underlying mechanisms. PANoptosis, a newly defined form of programmed cell death that integrates pyroptosis, apoptosis, and necroptosis, may play a crucial ...
BACKGROUND: DNA methylation has shown great potential in Alzheimer's disease (AD) blood diagnosis. However, the ability of long non-coding RNAs (lncRNAs), which can be modified by DNA methylation, to serve as noninvasive biomarkers for AD diagnosis r...
BACKGROUND AND OBJECTIVES: The choroid plexus (ChP) plays a crucial role in maintaining brain health. Alzheimer disease (AD) pathologies may damage the ChP and accelerate neurodegeneration. Previous imaging studies have found overall increased ChP vo...
The lack of safe, durable therapeutics that act against both biological aging and Alzheimer's disease is an unmet clinical need. To bridge this gap, we devised an artificial intelligence (AI)-enabled approach that pairs rapid compound triage with mec...
Biomedical physics & engineering express
Nov 19, 2025
Artificial intelligence (AI) systems are increasingly used in medical imaging for disease diagnosis, yet their vulnerability to adversarial attacks poses significant risks for clinical deployment. In this work, we systematically evaluate the suscepti...
High-throughput analysis of EEG data has significantly contributed to understanding neural dynamics in Alzheimer's disease diagnosis. However, the complexity and high dimensionality of EEG signals pose challenges for traditional classification method...
Neurofilament light chain (NfL), a cytoskeletal protein released during neuronal injury, is a promising biomarker, with elevated levels consistently associated with disease severity and progression in multiple neurological conditions, including Alzhe...
Journal of chemical information and modeling
Nov 6, 2025
Drug repositioning accelerates therapeutic discovery, but existing computational methods are hampered by representation collapse, noisy supervision, and suboptimal negative sampling. To address these limitations, we introduce MGTAL-DR, a novel graph ...
Alzheimer's disease (AD) is a progressive neurodegenerative disorder in which amyloid-β (Aβ) aggregation plays a pivotal role in its onset and progression. Inhibiting Aβ aggregation is a promising therapeutic strategy; however, its intrinsically diso...
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