OBJECTIVES: Reliable detection of disease-specific atrophy in individual T1w-MRI by voxel-based morphometry (VBM) requires scanner-specific normal databases (NDB), which often are not available. The aim of this retrospective study was to design, trai...
IEEE journal of biomedical and health informatics
Nov 7, 2023
PET-based Alzheimer's disease (AD) assessment has many limitations in large-scale screening. Non-invasive techniques such as resting-state functional magnetic resonance imaging (rs-fMRI) have been proven valuable in early AD diagnosis. This study inv...
The major issue faced by elderly people in society is the loss of memory, difficulty learning new things, and poor judgment. This is due to damage to brain tissues, which may lead to cognitive impairment and eventually Alzheimer's. Therefore, the det...
IMPORTANCE: Predictive models using machine learning techniques have potential to improve early detection and management of Alzheimer disease (AD). However, these models potentially have biases and may perpetuate or exacerbate existing disparities.
Mild cognitive impairment (MCI) is the precursor to the advanced stage of Alzheimer's disease (AD), and it is important to detect the transition to the MCI condition as early as possible. Trends in daily routines/activities provide a measurement of c...
BACKGROUND: Genotypes are strongly associated with disease phenotypes, particularly in brain disorders. However, the molecular and cellular mechanisms behind this association remain elusive. With emerging multimodal data for these mechanisms, machine...
The accurate prediction of patients with complex diseases, such as Alzheimer's disease (AD), as well as disease stages, including early- and late-stage cancer, is challenging owing to substantial variability among patients and limited availability of...
Previous studies revealed that hormone replacement therapy (HRT) probably has a protective effect for preventing dementia in post-menopausal women. However, the results were still controversial. The association between cholesterol levels and incident...
PURPOSE: The aim of this study is to develop a deep neural network to diagnosis Alzheimer's disease and categorize the stages of the disease using FDG-PET scans. Fluorodeoxyglucose positron emission tomography (FDG-PET) is a highly effective diagnost...
BACKGROUND: Alzheimer's disease (AD) is an incurable, debilitating neurodegenerative disorder. Current biomarkers for AD diagnosis require expensive neuroimaging or invasive cerebrospinal fluid sampling, thus precluding early detection. Blood-based b...